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Exogenous wild-type p53 gene improved survival of nude mice injected with murine erythroleukemia cell line through amelioration of hemorheological changes
Zhang, Yingyu1; Yao, Weijuan1; Zeng, Zhu1; Wang, Xianwei1; Sun, Dagong1; Ka, Weibo1; Zhou, Shupei1; He, Dongqi1; Wen, Zongyao1; Chien, Shu1
关键词erythroleukemia hemorheology human wild-type p53 gene murine erythroleukemia cells (MEL) nude mice
刊名MICROCIRCULATION
2007-02-01
DOI10.1080/10739680601139104
14期:2页:155-166
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]HUMAN CANCER-CELLS ; SHEAR-FLOW FIELD ; LOW-VISCOSITY ; ERYTHROCYTE DEFORMABILITY ; RBC MEMBRANE ; EKTACYTOMETRY ; POLARIZATION ; ORIENTATION ; INDUCTION ; APOPTOSIS
英文摘要

Objectives: Previous investigations have shown that human wild-type p53 gene (WTp53) inhibits the growth of leukemia and tumor cells in vitro. In the present: study; the authors used nude mice and examined the therapeutic role of p53 gene for erythroleukemia ill vivo in the absence of MHC effects.

Methods: The dude mice Were injected with murine erythroleukemia cells (MEL), MFL cells transfected with wild-type p53 gene (MEL-W), and MEL cells transfected with mutated p53 gene (MEL-M). Abnormalities were found in the hemorheological and biophysical properties of red blood cells in all :3 groups of animals; but: the abnormalities were lesser ill degree and later in appearance in MEL-W group than in MEL and MEL-M groups. Futhermore, the nude mice in MEL-W group lived longer than those ill MEL and MEL-M groups.

Results: The results showed that: WTp53 restrained the growth of erythroleukemia cells in vivo and reduced the erythroleukemia tumorigenesis in the microcirculation by improving the hemorheological and biophysical properties of MEL cells; which helped to prolong the life span of nude mice suffering from erythroleukemia.

Conclusion: These results contribute to our knowledge on the use of wild-type p53 gene for the treatment of erythroleukemia disease.

语种英语
WOS记录号WOS:000244690400008
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51377
专题基础医学院_生物物理学系
作者单位1.Peking Univ, Dept Biophys, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Dept Med Phys, Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Dept Med Phys, Dept Expt Anim, Beijing 100083, Peoples R China
4.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
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GB/T 7714
Zhang, Yingyu,Yao, Weijuan,Zeng, Zhu,et al. Exogenous wild-type p53 gene improved survival of nude mice injected with murine erythroleukemia cell line through amelioration of hemorheological changes[J]. MICROCIRCULATION,2007,14(2):155-166.
APA Zhang, Yingyu.,Yao, Weijuan.,Zeng, Zhu.,Wang, Xianwei.,Sun, Dagong.,...&Chien, Shu.(2007).Exogenous wild-type p53 gene improved survival of nude mice injected with murine erythroleukemia cell line through amelioration of hemorheological changes.MICROCIRCULATION,14(2),155-166.
MLA Zhang, Yingyu,et al."Exogenous wild-type p53 gene improved survival of nude mice injected with murine erythroleukemia cell line through amelioration of hemorheological changes".MICROCIRCULATION 14.2(2007):155-166.
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