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Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk
Yuasa, Yasuhito1; Nagasaki, Hiromi1; Oze, Isao1; Akiyama, Yoshimitsu1; Yoshida, Shunsuke1; Shitara, Kouhei1; Ito, Seiji1; Hosono, Satoyo1; Watanabe, Miki1; Ito, Hidemi1; Tanaka, Hideo1; Kang, Daehee2; Pan, Kai-feng3; You, Wei-cheng3; Matsuo, Keitaro1
关键词Dna Methylation Gastric Cancer Igf2 Blood Leukocyte Lifestyle
刊名INTERNATIONAL JOURNAL OF CANCER
2012-12-01
DOI10.1002/ijc.27554
131期:11页:2596-2603
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DIETARY FACTORS ; METHYLATION STATUS ; COLORECTAL-CANCER ; FACTOR-II ; GENE ; IGF2 ; CARCINOGENESIS ; EPIGENETICS ; CARCINOMA ; EVENTS
英文摘要

To determine whether or not the methylation status of blood leukocyte DNA can be used as a surrogate marker of the risk for cancer, we quantitatively determined the methylation levels of insulin-like growth factor 2 (IGF2) and TUSC3 in 299 gastric cancer cases, and 299 age- and gender-matched controls. The IGF2 methylation levels in blood leukocyte DNA of the cases were lower than those of the healthy controls and there was a significant trend of increasing gastric cancer risk with decreasing methylation level of IGF2. Patients with hypermethylated IGF2 in blood leukocyte DNA showed a significantly better survival rate than those with hypomethylated IGF2, indicating that the IGF2 methylation level in blood leukocyte DNA can be a possible marker not only of the risk for but also of the prognosis of gastric cancer. In contrast, the TUSC3 methylation level in blood leukocyte DNA was higher in the cases than in the healthy controls, but the difference was not significant. The past lifestyle and clinicopathological characteristics of the participants were analyzed for any relationship with the methylation level. With aging and smoking, methylation of IGF2 and TUSC3 decreased and increased in blood leukocyte DNA, respectively. These results indicate that the methylation level of IGF2 in blood leukocyte DNA may be used as an important surrogate marker of the risk for gastric cancer.

语种英语
WOS记录号WOS:000309185400014
项目编号17015013 ; 20390169 ; AA005 ; 00001
资助机构Ministry of Education, Culture, Sports, Science and Technology of Japan ; Japan Society for the Promotion of Science ; Ministry of Health, Labor, and Welfare of Japan
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51379
专题北京大学临床肿瘤学院_流行病学研究室
北京大学临床肿瘤学院_党院办公室
作者单位1.Tokyo Med & Dent Univ, Dept Mol Oncol, Bunkyo Ku, Tokyo 1138519, Japan
2.Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea
3.Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Beijing 100871, Peoples R China
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GB/T 7714
Yuasa, Yasuhito,Nagasaki, Hiromi,Oze, Isao,et al. Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk[J]. INTERNATIONAL JOURNAL OF CANCER,2012,131(11):2596-2603.
APA Yuasa, Yasuhito.,Nagasaki, Hiromi.,Oze, Isao.,Akiyama, Yoshimitsu.,Yoshida, Shunsuke.,...&Matsuo, Keitaro.(2012).Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk.INTERNATIONAL JOURNAL OF CANCER,131(11),2596-2603.
MLA Yuasa, Yasuhito,et al."Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk".INTERNATIONAL JOURNAL OF CANCER 131.11(2012):2596-2603.
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