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IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk
作者: Yuasa, Yasuhito1; Nagasaki, Hiromi1; Oze, Isao1; Akiyama, Yoshimitsu1; Yoshida, Shunsuke1; Shitara, Kouhei1; Ito, Seiji1; Hosono, Satoyo1; Watanabe, Miki1; Ito, Hidemi1; Tanaka, Hideo1; Kang, Daehee2; Pan, Kai-feng3; You, Wei-cheng3; Matsuo, Keitaro1
关键词: DNA methylation ; gastric cancer ; IGF2 ; blood leukocyte ; lifestyle
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2012-12-01
DOI: 10.1002/ijc.27554
卷: 131, 期:11, 页:2596-2603
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: DIETARY FACTORS ; METHYLATION STATUS ; COLORECTAL-CANCER ; FACTOR-II ; GENE ; IGF2 ; CARCINOGENESIS ; EPIGENETICS ; CARCINOMA ; EVENTS
英文摘要:

To determine whether or not the methylation status of blood leukocyte DNA can be used as a surrogate marker of the risk for cancer, we quantitatively determined the methylation levels of insulin-like growth factor 2 (IGF2) and TUSC3 in 299 gastric cancer cases, and 299 age- and gender-matched controls. The IGF2 methylation levels in blood leukocyte DNA of the cases were lower than those of the healthy controls and there was a significant trend of increasing gastric cancer risk with decreasing methylation level of IGF2. Patients with hypermethylated IGF2 in blood leukocyte DNA showed a significantly better survival rate than those with hypomethylated IGF2, indicating that the IGF2 methylation level in blood leukocyte DNA can be a possible marker not only of the risk for but also of the prognosis of gastric cancer. In contrast, the TUSC3 methylation level in blood leukocyte DNA was higher in the cases than in the healthy controls, but the difference was not significant. The past lifestyle and clinicopathological characteristics of the participants were analyzed for any relationship with the methylation level. With aging and smoking, methylation of IGF2 and TUSC3 decreased and increased in blood leukocyte DNA, respectively. These results indicate that the methylation level of IGF2 in blood leukocyte DNA may be used as an important surrogate marker of the risk for gastric cancer.

语种: 英语
所属项目编号: 17015013 ; 20390169 ; AA005 ; 00001
项目资助者: Ministry of Education, Culture, Sports, Science and Technology of Japan ; Japan Society for the Promotion of Science ; Ministry of Health, Labor, and Welfare of Japan
WOS记录号: WOS:000309185400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51379
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: 1.Tokyo Med & Dent Univ, Dept Mol Oncol, Bunkyo Ku, Tokyo 1138519, Japan
2.Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea
3.Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Beijing 100871, Peoples R China

Recommended Citation:
Yuasa, Yasuhito,Nagasaki, Hiromi,Oze, Isao,et al. Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk[J]. INTERNATIONAL JOURNAL OF CANCER,2012,131(11):2596-2603.
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