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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE
作者: Yang, Zhi-Jian1; Xu, Shun-Lin2; Chen, Bo1; Zhang, Shu-Lan1; Zhang, You-Long1; Wei, Wang1; Ma, Dong-Chao1; Wang, Lian-Sheng1; Zhu, Tie-Bing1; Li, Chun-Jian1; Wang, Hui1; Cao, Ke-Jiang1; Gao, Wei2; Huang, Jun1; Ma, Wen-Zhu1; Wu, Zu-Ze3
关键词: coronary heart disease ; cytokines ; endothelial progenitor cell mobilization ; gene therapy ; hepatocyte growth factor
刊名: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
发表日期: 2009-08-01
DOI: 10.1111/j.1440-1681.2009.05151.x
卷: 36, 期:8, 页:790-796
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Physiology
研究领域[WOS]: Pharmacology & Pharmacy ; Physiology
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; PERIPHERAL ARTERIAL-DISEASE ; SMOOTH-MUSCLE-CELLS ; C-MET(+) STEM-CELLS ; LIMB ISCHEMIA MODEL ; CARDIAC DYSFUNCTION ; UP-REGULATION ; RAT MODEL ; ANGIOGENESIS
英文摘要:

P>There is growing evidence of the beneficial effects of hepatocyte growth factor (HGF) in myocardial infarction, heart failure and occlusive peripheral arterial disease. The aim of the present study was to evaluate the effects of intracoronary administration of an adenovirus vector encoding the human HGF gene (Ad-HGF) on serum levels of cytokines and mobilization of CD34(+) and CD117(+) cells in patients with coronary heart disease.

Twenty-one patients with severe coronary artery disease were recruited to the study: 11 patients received both a stent and administration of Ad-HGF; the remaining 10 patients received a stent alone and served as the control group. Blood samples were obtained from the femoral vein before and then 6 and 24 h, 3 and 6 days and 2 weeks after treatment for the isolation of serum and peripheral blood mononuclear cells. Intracoronary administration of Ad-HGF in patients with coronary heart disease resulted in high levels of HGF gene expression, as well as its receptor c-met, compared with the control group, as demonstrated by real-time reverse transcription-polymerase chain reaction. In addition, serum levels of HGF, vascular endothelial growth factor, monocyte chemoattractant protein-1 and interleukin (IL)-10 were increased and serum levels of IL-8 were decreased in patients administered Ad-HGF compared with the control group. The percentage of CD34(+) and CD117(+) cells in the peripheral blood increased in patients administered Ad-HGF.

In conclusion, HGF gene therapy may play an important role in the regulation of cytokines and the induction of endothelial progenitor cell mobilization in patients with coronary heart disease.

语种: 英语
所属项目编号: 2004CB518801
项目资助者: Medical Key Member of the Medicine Renaissance Projects of Jiangsu Province ; Chinese National Basic Research and Development
WOS记录号: WOS:000268458200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51381
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiovasc Med, Nanjing 210029, Jiangsu Prov, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiovasc Med, Beijing 100871, Peoples R China
3.Acad Mil Med Sci, Beijing Inst Radiat Med Chinese, Beijing, Peoples R China

Recommended Citation:
Yang, Zhi-Jian,Xu, Shun-Lin,Chen, Bo,et al. HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2009,36(8):790-796.
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