IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE
Yang, Zhi-Jian1; Xu, Shun-Lin2; Chen, Bo1; Zhang, Shu-Lan1; Zhang, You-Long1; Wei, Wang1; Ma, Dong-Chao1; Wang, Lian-Sheng1; Zhu, Tie-Bing1; Li, Chun-Jian1; Wang, Hui1; Cao, Ke-Jiang1; Gao, Wei2; Huang, Jun1; Ma, Wen-Zhu1; Wu, Zu-Ze3
关键词Coronary Heart Disease Cytokines Endothelial Progenitor Cell Mobilization Gene Therapy Hepatocyte Growth Factor
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2009-08-01
DOI10.1111/j.1440-1681.2009.05151.x
36期:8页:790-796
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; PERIPHERAL ARTERIAL-DISEASE ; SMOOTH-MUSCLE-CELLS ; C-MET(+) STEM-CELLS ; LIMB ISCHEMIA MODEL ; CARDIAC DYSFUNCTION ; UP-REGULATION ; RAT MODEL ; ANGIOGENESIS
英文摘要

P>There is growing evidence of the beneficial effects of hepatocyte growth factor (HGF) in myocardial infarction, heart failure and occlusive peripheral arterial disease. The aim of the present study was to evaluate the effects of intracoronary administration of an adenovirus vector encoding the human HGF gene (Ad-HGF) on serum levels of cytokines and mobilization of CD34(+) and CD117(+) cells in patients with coronary heart disease.

Twenty-one patients with severe coronary artery disease were recruited to the study: 11 patients received both a stent and administration of Ad-HGF; the remaining 10 patients received a stent alone and served as the control group. Blood samples were obtained from the femoral vein before and then 6 and 24 h, 3 and 6 days and 2 weeks after treatment for the isolation of serum and peripheral blood mononuclear cells. Intracoronary administration of Ad-HGF in patients with coronary heart disease resulted in high levels of HGF gene expression, as well as its receptor c-met, compared with the control group, as demonstrated by real-time reverse transcription-polymerase chain reaction. In addition, serum levels of HGF, vascular endothelial growth factor, monocyte chemoattractant protein-1 and interleukin (IL)-10 were increased and serum levels of IL-8 were decreased in patients administered Ad-HGF compared with the control group. The percentage of CD34(+) and CD117(+) cells in the peripheral blood increased in patients administered Ad-HGF.

In conclusion, HGF gene therapy may play an important role in the regulation of cytokines and the induction of endothelial progenitor cell mobilization in patients with coronary heart disease.

语种英语
WOS记录号WOS:000268458200012
项目编号2004CB518801
资助机构Medical Key Member of the Medicine Renaissance Projects of Jiangsu Province ; Chinese National Basic Research and Development
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51381
专题北京大学第三临床医学院_心血管内科
作者单位1.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiovasc Med, Nanjing 210029, Jiangsu Prov, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiovasc Med, Beijing 100871, Peoples R China
3.Acad Mil Med Sci, Beijing Inst Radiat Med Chinese, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yang, Zhi-Jian,Xu, Shun-Lin,Chen, Bo,et al. HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2009,36(8):790-796.
APA Yang, Zhi-Jian.,Xu, Shun-Lin.,Chen, Bo.,Zhang, Shu-Lan.,Zhang, You-Long.,...&Wu, Zu-Ze.(2009).HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,36(8),790-796.
MLA Yang, Zhi-Jian,et al."HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 36.8(2009):790-796.
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