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Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients
Zhu Hong-lan; Wang Yan; Li Xiao-ping; Wang Chao-hua; Wang Yue; Cui Heng; Wang Jian-liu; Wei Li-hui
关键词Gonadotropin-releasing Hormone Agonists Fertility Preservation Chemotherapy Borderline Ovarian Tumor Ovarian Cancer
刊名CHINESE MEDICAL JOURNAL
2013-02-20
DOI10.3760/cma.j.issn.0366-6999.20122738
126期:4页:688-691
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]FERTILITY PRESERVATION ; YOUNG-WOMEN ; PREVENTION ; DAMAGE ; GONADOTOXICITY ; PROTECTION ; LYMPHOMA
英文摘要

Background Recently, conservative surgery is acceptable in young patients with borderline ovarian tumor and ovarian cancer. The preservation of these patients′ future fertility has been the focus of recent interest. This study aimed to observe the effect of gonadotropin-releasing hormone agonists (GnRHa) cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients.

Methods Sixteen patients who were treated with fertility preservation surgery for borderline ovarian tumor and ovarian cancer and then administered GnRHa during chemotherapy in Peking University People′s Hospital from January 2006 to July 2010 were retrospectively analyzed. This group was compared with a control group of 16 women who were treated concurrently with similar chemotherapy (n=5) without GnRHa or were historical controls (n=11). The disease recurrence, the menstruation status and reproductive outcome were followed up and compared between the two groups.

Results There were no significant differences between both groups regarding age, body weight, height, marriage status, classification of the tumors, stage of the disease, as were the cumulative doses of each chemotherapeutic agent. One (1/16) patient in the study group while 2 (2/16) patients in the control group relapsed 2 years after conclusion of the primary treatment (P >0.05). All of the 16 women in the study group compared with 11 of the 16 patients in the control group resumed normal menses 6 months after the termination of the treatment (P <0.05). There were 4 spontaneous pregnancies in the study group while 2 in the control group, all of the neonates were healthy.

Conclusions GnRHa administration before and during chemotherapy in borderline ovarian tumor and ovarian cancer patients who had undergone fertility preservation operation may bring up higher rates of spontaneous resumption of menses and a better pregnancy rate. Long-term follow up and large scale clinical studies are required.

语种英语
WOS记录号WOS:000319793800016
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51382
专题北京大学第二临床医学院
北京大学医学部管理机构_计划财务处
北京大学第二临床医学院_妇科
作者单位Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
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Zhu Hong-lan,Wang Yan,Li Xiao-ping,et al. Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients[J]. CHINESE MEDICAL JOURNAL,2013,126(4):688-691.
APA Zhu Hong-lan.,Wang Yan.,Li Xiao-ping.,Wang Chao-hua.,Wang Yue.,...&Wei Li-hui.(2013).Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients.CHINESE MEDICAL JOURNAL,126(4),688-691.
MLA Zhu Hong-lan,et al."Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients".CHINESE MEDICAL JOURNAL 126.4(2013):688-691.
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