北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 药剂科  > 期刊论文
学科主题: 临床医学
题名:
Effects of CYP2C19 Loss-of-Function Variants on the Eradication of H. pylori Infection in Patients Treated with Proton Pump Inhibitor-Based Triple Therapy Regimens: A Meta-Analysis of Randomized Clinical Trials
作者: Tang, Hui-Lin1; Li, Yan1; Hu, Yong-Fang1; Xie, Hong-Guang2,3,4; Zhai, Suo-Di1
刊名: PLOS ONE
发表日期: 2013-04-30
DOI: 10.1371/journal.pone.0062162
卷: 8, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HELICOBACTER-PYLORI ; GENETIC-POLYMORPHISM ; INTERLEUKIN-1 POLYMORPHISMS ; CLARITHROMYCIN RESISTANCE ; CYTOCHROME P2C19 ; GASTRIC-JUICE ; CURE RATES ; RABEPRAZOLE ; AMOXICILLIN ; OMEPRAZOLE
英文摘要:

Background: There are inconsistent conclusions about whether CYP2C19 variants could affect H. pylori eradication rate in patients treated with the proton pump inhibitor (PPI)-based therapy. We therefore performed a meta-analysis of randomized clinical trials (RCTs) to re-evaluate the impact of CYP2C19 variants on PPI-based triple therapy for the above indication.

Methods: All relevant RCTs in the PubMed, Cochrane Library, EMBASE, Web of Science and two Chinese databases (up to February 2013) were systematically searched, and a pooled analysis was performed with the odds ratio (OR) and 95% confidence interval (CI) by the STATA software.

Results: Sixteen RCT datasets derived from 3680 patients were included. There was no significant heterogeneity across the data available in this meta-analysis. There were significant differences in that rate between homozygous (HomEMs) and heterozygous (HetEMs) extensive metabolizers (OR 0.724; 95% CI 0.594-0.881), between HomEMs and poor metabolizers (PM) (OR 0.507; 95% CI 0.379-0.679), or between HetEMs and PMs (OR 0.688; 95% CI 0.515-0.920), regardless of the PPI being taken. Furthermore, sub-analysis of individual PPIs was carried out to explore the difference across all the PPIs used. A significantly low rate was seen in HomEMs vs. HetEMs taking either omeprazole (OR 0.329; 95% CI 0.195-0.553) or lansoprazole (OR 0.692; 95% CI 0.485-0.988), and also in HomEMs vs. PMs for omeprazole (OR 0.232; 95% CI 0.105-0.515) or lansoprazole (OR 0.441; 95% CI 0.252-0.771). However, there was no significant difference between HetEMs and PMs taking either one. No significant differences were observed for rabeprazole or esomeprazole across the CYP2C19 genotypes of interest.

Conclusions: Carriage of CYP2C19 loss-of-function variants is associated with increased H. pylori eradication rate in patients taking PPI-based triple therapies when omeprazole or lansoprazole is chosen. However, there is no a class effect after use of rabeprazole or esomeprazole.

语种: 英语
WOS记录号: WOS:000319077300028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51384
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Pharm, Therapeut Drug Monitoring & Clin Toxicol Ctr, Hosp 3, Beijing 100871, Peoples R China
2.Nanjing Med Univ, Nanjing Hosp 1, Gen Clin Res Ctr, Nanjing, Jiangsu, Peoples R China
3.Nanjing Med Univ, Nanjing Hosp 1, Div Clin Pharmacol, Nanjing, Jiangsu, Peoples R China
4.Nanjing Med Univ, Sch Pharm, Dept Pharmacol, Nanjing, Jiangsu, Peoples R China

Recommended Citation:
Tang, Hui-Lin,Li, Yan,Hu, Yong-Fang,et al. Effects of CYP2C19 Loss-of-Function Variants on the Eradication of H. pylori Infection in Patients Treated with Proton Pump Inhibitor-Based Triple Therapy Regimens: A Meta-Analysis of Randomized Clinical Trials[J]. PLOS ONE,2013,8(4).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tang, Hui-Lin]'s Articles
[Li, Yan]'s Articles
[Hu, Yong-Fang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tang, Hui-Lin]‘s Articles
[Li, Yan]‘s Articles
[Hu, Yong-Fang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace