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学科主题: 药学
题名:
Artificial Transcription Factors which Mediate Double-Strand DNA Cleavage
作者: Li, Chao1; Du, Chao1; Tian, Hua1; Jiang, Chao1; Du, Min1; Liu, Yan3,4; Qiao, Ren-Zhong1,2; Jia, Yan-Xing2; Zhao, Yu-Fen3,4
关键词: artificial transcription factors ; DNA binding ; DNA cleavage ; double-strand cleavage ; polyamide
刊名: CHEMISTRY-A EUROPEAN JOURNAL
发表日期: 2010
DOI: 10.1002/chem.201000552
卷: 16, 期:43, 页:12935-12940
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: PYRROLE-IMIDAZOLE POLYAMIDES ; 6-ZINC FINGER PEPTIDES ; SMALL-MOLECULE ; MINOR-GROOVE ; PLASMID DNA ; BINDING ; RECOGNITION ; DESIGN ; DOMAIN ; HYDROLYSIS
英文摘要:

A new family of artificial transcription factor (ATF)-based conjugates have been designed and synthesized as potent chemical nucleases. Polyamides as the important and efficient ATFs were used to modify and activate several anchor compounds. The results demonstrate that the resulting conjugates remarkably promote the rate accelerations and non-random double-strand DNA cleavage activity. Interestingly, the cleavage activity of both the hydrolytic and oxidative agents was promoted efficiently through the modification of the ATFs.

语种: 英语
所属项目编号: 20732004 ; 20872010 ; 20972014
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000284063900023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51385
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China
4.Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

Recommended Citation:
Li, Chao,Du, Chao,Tian, Hua,et al. Artificial Transcription Factors which Mediate Double-Strand DNA Cleavage[J]. CHEMISTRY-A EUROPEAN JOURNAL,2010,16(43):12935-12940.
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