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Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria
Xin, G1; Wang, M1; Jiao, LL1; Xu, GB1; Wang, HY1
关键词Proteinuria Urinary Protein Excretion Urine Protein-to-creatinine Ratio
刊名CLINICA CHIMICA ACTA
2004-12-01
DOI10.1016/j.cccn.2004.06.019
350期:1-2页:35-39
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]DIABETIC-NEPHROPATHY ; EXCRETION
英文摘要

Background: Normal individuals usually excrete very small amounts of protein in the urine. Persistently increased protein excretion is usually a marker of kidney damage. Quantifying protein in urine is commonly used in the diagnosis of kidney diseases, detection of treatment effects and evaluation of prognosis. We evaluated the use of the total protein-to-creatinine ratio (P/C) in spot urine specimens as a predictor of urine protein excretion in 24-h collections.

Methods: The correlation between P/C in first morning and random urine specimens and urinary protein excretion in 24-h collections were analyzed. The cutoff value of P/C in first morning urine specimens for screening urinary protein excretion of I and 3 g in 24-h collections was determined by receiver operating characteristics (ROC) curve.

Results: For patients with Ccr less than or equal to 10 ml/min, correlation between the urine protein excretion in 24-h collections and the P/C in first morning urine specimens was not significant. For patients with Ccr > 10 ml/min, the correlation was highly significant. Similar results were obtained for random urine specimens. By ROC curve analysis, the P/C of 0.94 and 2.84 g/gcr in first morning urine specimens represent the best threshold to detect urine protein excretion of 1 and 3 g in 24-h collections, respectively. There is a good correlation between P/C in first morning urine specimens and random urine specimens from inpatients and outpatients. But the P/C in random specimens is significantly higher than that in first morning specimens in outpatients.

Conclusion: The P/C in spot urine samples could be used as an alternative to urine protein excretion in 24-h collections in patients with Ccr >10 ml/min. The P/C in first morning urine samples is better than that in random specimens, especially for outpatients. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000225581500003
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51387
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_检验科
作者单位1.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xin, G,Wang, M,Jiao, LL,et al. Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria[J]. CLINICA CHIMICA ACTA,2004,350(1-2):35-39.
APA Xin, G,Wang, M,Jiao, LL,Xu, GB,&Wang, HY.(2004).Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria.CLINICA CHIMICA ACTA,350(1-2),35-39.
MLA Xin, G,et al."Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria".CLINICA CHIMICA ACTA 350.1-2(2004):35-39.
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