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学科主题: 临床医学
题名:
Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria
作者: Xin, G1; Wang, M1; Jiao, LL1; Xu, GB1; Wang, HY1
关键词: proteinuria ; urinary protein excretion ; urine protein-to-creatinine ratio
刊名: CLINICA CHIMICA ACTA
发表日期: 2004-12-01
DOI: 10.1016/j.cccn.2004.06.019
卷: 350, 期:1-2, 页:35-39
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: DIABETIC-NEPHROPATHY ; EXCRETION
英文摘要:

Background: Normal individuals usually excrete very small amounts of protein in the urine. Persistently increased protein excretion is usually a marker of kidney damage. Quantifying protein in urine is commonly used in the diagnosis of kidney diseases, detection of treatment effects and evaluation of prognosis. We evaluated the use of the total protein-to-creatinine ratio (P/C) in spot urine specimens as a predictor of urine protein excretion in 24-h collections.

Methods: The correlation between P/C in first morning and random urine specimens and urinary protein excretion in 24-h collections were analyzed. The cutoff value of P/C in first morning urine specimens for screening urinary protein excretion of I and 3 g in 24-h collections was determined by receiver operating characteristics (ROC) curve.

Results: For patients with Ccr less than or equal to 10 ml/min, correlation between the urine protein excretion in 24-h collections and the P/C in first morning urine specimens was not significant. For patients with Ccr > 10 ml/min, the correlation was highly significant. Similar results were obtained for random urine specimens. By ROC curve analysis, the P/C of 0.94 and 2.84 g/gcr in first morning urine specimens represent the best threshold to detect urine protein excretion of 1 and 3 g in 24-h collections, respectively. There is a good correlation between P/C in first morning urine specimens and random urine specimens from inpatients and outpatients. But the P/C in random specimens is significantly higher than that in first morning specimens in outpatients.

Conclusion: The P/C in spot urine samples could be used as an alternative to urine protein excretion in 24-h collections in patients with Ccr >10 ml/min. The P/C in first morning urine samples is better than that in random specimens, especially for outpatients. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000225581500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51387
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Xin, G,Wang, M,Jiao, LL,et al. Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria[J]. CLINICA CHIMICA ACTA,2004,350(1-2):35-39.
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