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Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats
Sun, Hong2; Che, Qing-Ming3; Zhao, Xin2; Pu, Xiao-Ping1,2
关键词Baicalein Carbon Tetrachloride Liver Fibrosis
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2010-04-10
DOI10.1016/j.ejphar.2010.01.002
631期:1-3页:53-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Program of China f ; National Program of China f
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HEPATIC STELLATE CELLS ; SAIKO-TO TJ-9 ; HEPATOCELLULAR-CARCINOMA ; GROWTH-FACTOR ; EXPRESSION ; METALLOPROTEINASE ; INHIBITORS ; COLLAGEN ; DISEASE ; DRUG
英文摘要

Baicalein was a major bioactive flavonoid derived from Radix Scutellariae in Xiao-Chai-Hu-Tang which was commonly used to treat chronic hepatitis and liver fibrosis in China. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl4) in rats and investigate its possible protective mechanism. The antifibrotic effects of baicalein were assessed directly by hepatic histology and indirectly by measuring levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), hepatic hyaluronic acid, laminin and procollagen type III (PCIII) in serum, as well as hydroxyproline and matrix metalloproteinases (MMPs) in liver. In addition, we further investigated protein synthesis of platelet derived growth factor (PDGF) beta receptor which has been identified as attractive target for therapeutic intervention. CCl4 treatment increased levels of AST, ALT, hyaluronic acid, laminin, and PCIII in serum, as well as hydroxyproline and MMPs in liver. Baicalein treatment (20, 40, or 80 mg/kg for 10 weeks) dose-dependently decreased levels of these markers. Baicalein also reduced inflammation, destruction of liver architecture, and collagen accumulation and significantly inhibited protein synthesis of PDGF-beta receptor. Together, our results suggest that chronic baicalein administration inhibits stellate cell activation and proliferation by the down-regulation of PDGF-P receptor and prevents the development of CCl4 induced liver fibrosis in rats. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2004CB518902
资助者National Program of China f ; National Program of China f
WOS记录号WOS:000275307100008
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51390
专题北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Hong,Che, Qing-Ming,Zhao, Xin,et al. Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,631(1-3):53-60.
APA Sun, Hong,Che, Qing-Ming,Zhao, Xin,&Pu, Xiao-Ping.(2010).Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,631(1-3),53-60.
MLA Sun, Hong,et al."Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 631.1-3(2010):53-60.
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