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Association between SYP with attention-deficit/hyperactivity disorder in Chinese Han subjects: Differences among subtypes and genders
Liu, Lu1,2; Chen, Yun1,2; Li, Haimei1,2; Qian, Qiujin1,2; Yang, Li1,2; Glatt, Stephen J.3,4; Faraone, Stephen V.3,4; Wang, Yufeng1,2
关键词Syp Adhd Inattentive Subtype Gender Association
刊名PSYCHIATRY RESEARCH
2013-11-30
DOI10.1016/j.psychres.2013.04.029
210期:1页:308-314
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]DEFICIT-HYPERACTIVITY-DISORDER ; RECEPTOR GENE ADRA2A ; DSM-IV SUBTYPES ; INATTENTIVE SUBTYPE ; TRANSPORTER GENE ; ADHD ; SYNAPTOPHYSIN ; POLYMORPHISMS ; HETEROGENEITY ; POPULATION
英文摘要

Dysfunction of neurotransmitters has been suggested to be involved in the etiology of attention-deficit/hyperactivity disorder (ADHD). Hence, genes encoding proteins involved in the vesicular release process of those neurotransmitters are attractive candidates in ADHD genetics. One of these genes is SYP, which encodes synaptophysin, a protein known to participate in regulating neurotransmitter release and synaptic plasticity. Several studies have reported an association between SYP and ADHD, but more work is needed to refine the association. In the present study, we attempt to investigate their association in Chinese Han subjects by family-based and case-control studies. Transmission disequilibrium tests (TDTs) in 1112 trios found significant association between SYP and the predominantly inattentive subtype (ADHD-I), especially for males with ADHD-I, both from single nucleotide polymorphism (SNP) and haplotypic analyses. Chi-square tests in 1682 ADHD probands and 957 comparison subjects indicated possible association of SYP with female ADHD and female ADHD-I. However, the associated alleles and haplotypes between males and females were reversed. In conclusion, our results suggested that SYP may be primarily associated with ADHD-I and its genetic mechanism may be gender-specific. Thus, it is necessary to take subtype and gender into account in ADHD genetic studies. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000326859400047
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51397
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA
4.SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA
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GB/T 7714
Liu, Lu,Chen, Yun,Li, Haimei,et al. Association between SYP with attention-deficit/hyperactivity disorder in Chinese Han subjects: Differences among subtypes and genders[J]. PSYCHIATRY RESEARCH,2013,210(1):308-314.
APA Liu, Lu.,Chen, Yun.,Li, Haimei.,Qian, Qiujin.,Yang, Li.,...&Wang, Yufeng.(2013).Association between SYP with attention-deficit/hyperactivity disorder in Chinese Han subjects: Differences among subtypes and genders.PSYCHIATRY RESEARCH,210(1),308-314.
MLA Liu, Lu,et al."Association between SYP with attention-deficit/hyperactivity disorder in Chinese Han subjects: Differences among subtypes and genders".PSYCHIATRY RESEARCH 210.1(2013):308-314.
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