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学科主题: 基础医学
题名:
A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents
作者: Dai, Hui1,2; Zhang, Yan1; Lv, Ping1; Gao, Xiao-Ming1,2
关键词: mouse ; autoantibody ; glucan ; autoimmune disease
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2009-12-01
卷: 6, 期:6, 页:453-459
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: CARBOHYDRATE ANTIGENS ; IMMUNE RECEPTORS ; BETA-GLUCANS ; POLYSACCHARIDES ; ANTITUMOR ; MICE ; MICROARRAY ; VACCINES ; MURINE ; LUPUS
英文摘要:

Inbred strains of mice and rats are widely used in preclinical investigations evaluating the effectiveness of glycan-based biomecines, however, the glycan specificity repertoires of serum Abs in rodents have not been fully characterized. In the present study, serum antibodies in naive mice and rats of different inbred strains were analyzed for specificity against 4 representative carbohydrate structures including PGA (1,4-linked alpha-D-galactopyranosyluronic acids), beta-glucan, mannan and alpha-glucan (dextran). Mannan was not recognized by serum Abs from any of the mouse and rat strains. Serum IgM in naive F344, BN and Lewis rats recognized PGA and beta-glucan and, less strongly, dextran. High titer circulating IgM against PGA were found in mice of BALB/c, C57BL/6, C3H/NeH and BXSB strains. C3H/NeH was the only strain which also produced low titer IgM against beta-glucan and dextran. Age-related production of high titer IgM, IgA and IgG Abs against beta-glucan was observed in BXSB mice. Intraperitoneal immunization of BALB/c and C57BL/6 mice with beta-glucan elicited strong IgM responses, while immunization with PGA also led to an increase of anti-PGA IgM Ab titers. These results provide useful information on the characteristics of glycan-specific natural antibody repertoires in rodents. Cellular & Molecular Immunology. 2009;6(6):453-459.

语种: 英语
所属项目编号: 2007CB512406 ; 2006AA02Z495 ; 30371303
项目资助者: National Key Basic Research Programs ; "863" Program ; Natural Science Foundation of China
WOS记录号: WOS:000274324300007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51401
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Minist Publ Hlth, Key Lab Immunol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Dai, Hui,Zhang, Yan,Lv, Ping,et al. A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(6):453-459.
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