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学科主题基础医学
A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents
Dai, Hui1,2; Zhang, Yan1; Lv, Ping1; Gao, Xiao-Ming1,2
关键词mouse autoantibody glucan autoimmune disease
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2009-12-01
6期:6页:453-459
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]CARBOHYDRATE ANTIGENS ; IMMUNE RECEPTORS ; BETA-GLUCANS ; POLYSACCHARIDES ; ANTITUMOR ; MICE ; MICROARRAY ; VACCINES ; MURINE ; LUPUS
英文摘要

Inbred strains of mice and rats are widely used in preclinical investigations evaluating the effectiveness of glycan-based biomecines, however, the glycan specificity repertoires of serum Abs in rodents have not been fully characterized. In the present study, serum antibodies in naive mice and rats of different inbred strains were analyzed for specificity against 4 representative carbohydrate structures including PGA (1,4-linked alpha-D-galactopyranosyluronic acids), beta-glucan, mannan and alpha-glucan (dextran). Mannan was not recognized by serum Abs from any of the mouse and rat strains. Serum IgM in naive F344, BN and Lewis rats recognized PGA and beta-glucan and, less strongly, dextran. High titer circulating IgM against PGA were found in mice of BALB/c, C57BL/6, C3H/NeH and BXSB strains. C3H/NeH was the only strain which also produced low titer IgM against beta-glucan and dextran. Age-related production of high titer IgM, IgA and IgG Abs against beta-glucan was observed in BXSB mice. Intraperitoneal immunization of BALB/c and C57BL/6 mice with beta-glucan elicited strong IgM responses, while immunization with PGA also led to an increase of anti-PGA IgM Ab titers. These results provide useful information on the characteristics of glycan-specific natural antibody repertoires in rodents. Cellular & Molecular Immunology. 2009;6(6):453-459.

语种英语
WOS记录号WOS:000274324300007
项目编号2007CB512406 ; 2006AA02Z495 ; 30371303
资助机构National Key Basic Research Programs ; "863" Program ; Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51401
专题北京大学基础医学院_免疫学系
作者单位1.Minist Publ Hlth, Key Lab Immunol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Dai, Hui,Zhang, Yan,Lv, Ping,et al. A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(6):453-459.
APA Dai, Hui,Zhang, Yan,Lv, Ping,&Gao, Xiao-Ming.(2009).A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents.CELLULAR & MOLECULAR IMMUNOLOGY,6(6),453-459.
MLA Dai, Hui,et al."A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents".CELLULAR & MOLECULAR IMMUNOLOGY 6.6(2009):453-459.
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