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学科主题: 临床医学
题名:
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
作者: Han, Jian-Wen1,2,3; Zheng, Hou-Feng1,2,3; Cui, Yong1,2,3; Sun, Liang-Dan1,2,3; Ye, Dong-Qing1,2,3; Hu, Zhi1,2,3; Xu, Jin-Hua4; Cai, Zhi-Ming5; Huang, Wei6; Zhao, Guo-Ping6; Xie, Hong-Fu7; Fang, Hong8; Lu, Qian-Jin9; Xu, Jian-Hua10; Li, Xiang-Pei11; Pan, Yun-Feng12; Deng, Dan-Qi13; Zeng, Fan-Qin14; Ye, Zhi-Zhong15; Zhang, Xiao-Yan16; Wang, Qing-Wen5; Hao, Fei17; Ma, Li16; Zuo, Xian-Bo1,2,3; Zhou, Fu-Sheng1,2,3; Du, Wen-Hui1,2,3; Cheng, Yi-Lin1,2,3; Yang, Jian-Qiang1,2,3; Shen, Song-Ke1,2,3; Li, Jian1,2,3; Sheng, Yu-Jun1,2,3; Zuo, Xiao-Xia7; Zhu, Wei-Fang8; Gao, Fei9; Zhang, Pei-Lian13; Guo, Qing14; Li, Bo15; Gao, Min1,2,3; Xiao, Feng-Li1,2,3; Quan, Cheng1,2,3; Zhang, Chi1,2,3; Zhang, Zheng1,2,3; Zhu, Kun-Ju1,2,3; Li, Yang1,2,3; Hu, Da-Yan1,2,3; Lu, Wen-Sheng1,2,3; Huang, Jian-Lin12; Liu, Sheng-Xiu1,2,3; Li, Hui1,2,3; Ren, Yun-Qing1,2,3; Wang, Zai-Xing1,2,3; Yang, Chun-Jun1,2,3; Wang, Pei-Guang1,2,3; Zhou, Wen-Ming1,2,3; Lv, Yong-Mei1,2,3; Zhang, An-Ping1,2,3; Zhang, Sheng-Quan1,2,3; Lin, Da1,2,3; Li, Yi18; Low, Hui Qi18; Shen, Min6; Zhai, Zhi-Fang17; Wang, Ying6; Zhang, Feng-Yu1,2,3; Yang, Sen1,2,3; Liu, Jian-Jun1,2,3; Zhang, Xue-Jun1,2,3,4
刊名: NATURE GENETICS
发表日期: 2009-11-01
DOI: 10.1038/ng.472
卷: 41, 期:11, 页:1234-U98
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: GENE ; VARIANTS ; ITGAM ; EPIDEMIOLOGY ; EXPRESSION ; PSORIASIS ; SCAN ; SLE ; PXK
英文摘要:

We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) <= P(combined) <= 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) <= P(combined) <= 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.

语种: 英语
所属项目编号: 30972727 ; 30530670 ; 30830089 ; 2007-7 ; TD200701
项目资助者: National Natural Science Foundation ; Anhui Provincial Special Scientific Program ; Anhui Skin Genetic Study Innovative Research Team Program
WOS记录号: WOS:000271247600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51405
Appears in Collections:北京大学深圳医院_风湿免疫科_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr Shanghai, Shanghai, Peoples R China
2.Genome Inst Singapore, Singapore, Singapore
3.Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China
4.Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China
5.Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China
6.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
7.Peking Univ, Shenzhen Hosp, Dept Rheumatol, Shenzhen, Guangdong, Peoples R China
8.Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China
9.Zhejiang Univ, Dept Dermatol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
10.Cent S Univ, Epigenet Res Ctr, Dept Dermatol, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
11.Anhui Med Univ, Dept Rheumatol, Hosp 1, Hefei, Anhui, Peoples R China
12.Anhui Med Univ, Dept Rheumatol, Affiliated Prov Hosp, Hefei, Anhui, Peoples R China
13.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Rheumatol, Guangzhou 510275, Guangdong, Peoples R China
14.Kunming Med Univ, Affiliated Hosp 2, Dept Dermatol, Kunming, Yunnan, Peoples R China
15.Sun Yat Sen Univ, Dept Dermatol, Affiliated Hosp 2, Guangzhou 510275, Guangdong, Peoples R China
16.Shenzhen Fourth Peoples Hosp, Dept Rheumatol, Shenzhen, Guangdong, Peoples R China
17.China Japan Friendship Hosp, Dept Dermatol, Beijing, Peoples R China
18.Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing, Peoples R China

Recommended Citation:
Han, Jian-Wen,Zheng, Hou-Feng,Cui, Yong,et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus[J]. NATURE GENETICS,2009,41(11):1234-U98.
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