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学科主题: 公共卫生
题名:
Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution
作者: Yu, Qingsong1,2; Dong, Chengyan3; Zhang, Jiajing1; Shi, Jiyun3; Jia, Bing3; Wang, Fan3; Gan, Zhihua1,2
刊名: POLYMER CHEMISTRY
发表日期: 2014-10-07
DOI: 10.1039/c4py00681j
卷: 5, 期:19, 页:5617-5627
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Polymer Science
研究领域[WOS]: Polymer Science
关键词[WOS]: DEX-G-PMAGGCONHTYR ; DRUG CARRIERS ; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS ; POLYMERIC NANOPARTICLES ; ANTITUMOR-ACTIVITY ; MOLECULAR-WEIGHT ; BLOOD CLEARANCE ; CELL-LINE ; CHARGE ; DOXORUBICIN
英文摘要:

Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P(H PMA-co-MAGG)) with different compositions and narrow polydispersity were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The in vivo blood clearance and biodistribution of copolymers with different compositions were studied in normal BALB/c mice. The results showed that the electronegative copolymers were rapidly eliminated from blood and tended to accumulate in the liver and spleen. However, the copolymers with neutral or a small amount of negative charges showed a prolonged circulation time and low non-specific organ uptake. Combined with the quantitative analysis of in vitro hepatocyte uptake, we conclude that this was due to the balance between (i) the electrostatic repulsion between the copolymer and the cell membrane and (ii) the tendency of macrophage-like cells to capture the negative charged copolymers. This work also revealed the significant roles of the PEG chain length, negative charge and molecular weight for the copolymers as anticancer drug carriers with prolonged circulation time and optimal biodistribution.

语种: 英语
所属项目编号: 51025314 ; 51390481 ; 50873109 ; 50830103 ; 30930030 ; KJCX2-YW-H19 ; 2011CB707703
项目资助者: Outstanding Youth Fund ; National Natural Science Foundations of China ; Chinese Academy of Sciences ; Ministry of Science and Technology of China
WOS记录号: WOS:000342481200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51406
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China
2.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Lab Biomat, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Qingsong,Dong, Chengyan,Zhang, Jiajing,et al. Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution[J]. POLYMER CHEMISTRY,2014,5(19):5617-5627.
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