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Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution
Yu, Qingsong1,2; Dong, Chengyan3; Zhang, Jiajing1; Shi, Jiyun3; Jia, Bing3; Wang, Fan3; Gan, Zhihua1,2
刊名POLYMER CHEMISTRY
2014-10-07
DOI10.1039/c4py00681j
5期:19页:5617-5627
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]DEX-G-PMAGGCONHTYR ; DRUG CARRIERS ; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS ; POLYMERIC NANOPARTICLES ; ANTITUMOR-ACTIVITY ; MOLECULAR-WEIGHT ; BLOOD CLEARANCE ; CELL-LINE ; CHARGE ; DOXORUBICIN
英文摘要

Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P(H PMA-co-MAGG)) with different compositions and narrow polydispersity were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The in vivo blood clearance and biodistribution of copolymers with different compositions were studied in normal BALB/c mice. The results showed that the electronegative copolymers were rapidly eliminated from blood and tended to accumulate in the liver and spleen. However, the copolymers with neutral or a small amount of negative charges showed a prolonged circulation time and low non-specific organ uptake. Combined with the quantitative analysis of in vitro hepatocyte uptake, we conclude that this was due to the balance between (i) the electrostatic repulsion between the copolymer and the cell membrane and (ii) the tendency of macrophage-like cells to capture the negative charged copolymers. This work also revealed the significant roles of the PEG chain length, negative charge and molecular weight for the copolymers as anticancer drug carriers with prolonged circulation time and optimal biodistribution.

语种英语
WOS记录号WOS:000342481200012
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51406
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China
2.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Lab Biomat, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yu, Qingsong,Dong, Chengyan,Zhang, Jiajing,et al. Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution[J]. POLYMER CHEMISTRY,2014,5(19):5617-5627.
APA Yu, Qingsong.,Dong, Chengyan.,Zhang, Jiajing.,Shi, Jiyun.,Jia, Bing.,...&Gan, Zhihua.(2014).Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution.POLYMER CHEMISTRY,5(19),5617-5627.
MLA Yu, Qingsong,et al."Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution".POLYMER CHEMISTRY 5.19(2014):5617-5627.
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