IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta)
Ji, Yanli1; Zhu, Yonghong1; Liang, Jingrui1; Wei, Xianfei2; Yang, Xi1; Wang, Ling1; Li, Lingjun1; Chang, Yibin1; Tang, Ronglan2; Zhuang, Hui1
关键词hepatitis E virus swine phylogeny pathogenicity Macaca mulatta
刊名JOURNAL OF GASTROENTEROLOGY
2008-07-01
DOI10.1007/s00535-008-2196-3
43期:7页:565-570
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]UNITED-STATES ; PREVALENCE ; HEV ; ANTIBODIES ; IDENTIFICATION ; SEQUENCES ; STRAINS ; HUMANS ; PIGS
英文摘要

Background. In rural areas of southern China, where hepatitis E is endemic, residents generally rear pigs in pigsties near their houses. The study was conducted to assess the possibility that hepatitis E virus (HEV) infections in this region are acquired primarily through contact with swine. Methods. One hundred twenty swine fecal samples collected from pigsties located in eight rural communities of southern China were tested for HEV RNA. The swine HEV isolates were analyzed genetically and were experimentally inoculated into rhesus monkeys to determine the potential risk of cross-species infection. Results. Twenty-nine of the 120 swine fecal samples were positive for HEV RNA. The nucleotide sequences of these swine HEV strains shared 85% 99% identities with the local human genotype 4 isolates and belonged to two subgroups of genotype 4. Importantly, swine HEV strains representing both subgroups induced hepatitis in rhesus monkeys by inoculation with the virus, evidenced by elevated serum alanine transaminase (ALT), viremia, fecal viral shedding, anti-HEV seroconversion, and liver histopathological changes. Conclusions. Swine may be the principal reservoir for human HEV infection in rural southern China.

语种英语
WOS记录号WOS:000258159500009
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51409
专题北京大学基础医学院_病原生物学系
作者单位1.Liuzhou Med Coll, Liuzhou 545000, Guangxi Prov, Peoples R China
2.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ji, Yanli,Zhu, Yonghong,Liang, Jingrui,et al. Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta)[J]. JOURNAL OF GASTROENTEROLOGY,2008,43(7):565-570.
APA Ji, Yanli.,Zhu, Yonghong.,Liang, Jingrui.,Wei, Xianfei.,Yang, Xi.,...&Zhuang, Hui.(2008).Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta).JOURNAL OF GASTROENTEROLOGY,43(7),565-570.
MLA Ji, Yanli,et al."Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta)".JOURNAL OF GASTROENTEROLOGY 43.7(2008):565-570.
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