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学科主题: 基础医学
题名:
Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta)
作者: Ji, Yanli1; Zhu, Yonghong1; Liang, Jingrui1; Wei, Xianfei2; Yang, Xi1; Wang, Ling1; Li, Lingjun1; Chang, Yibin1; Tang, Ronglan2; Zhuang, Hui1
关键词: hepatitis E virus ; swine ; phylogeny ; pathogenicity ; Macaca mulatta
刊名: JOURNAL OF GASTROENTEROLOGY
发表日期: 2008-07-01
DOI: 10.1007/s00535-008-2196-3
卷: 43, 期:7, 页:565-570
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: UNITED-STATES ; PREVALENCE ; HEV ; ANTIBODIES ; IDENTIFICATION ; SEQUENCES ; STRAINS ; HUMANS ; PIGS
英文摘要:

Background. In rural areas of southern China, where hepatitis E is endemic, residents generally rear pigs in pigsties near their houses. The study was conducted to assess the possibility that hepatitis E virus (HEV) infections in this region are acquired primarily through contact with swine. Methods. One hundred twenty swine fecal samples collected from pigsties located in eight rural communities of southern China were tested for HEV RNA. The swine HEV isolates were analyzed genetically and were experimentally inoculated into rhesus monkeys to determine the potential risk of cross-species infection. Results. Twenty-nine of the 120 swine fecal samples were positive for HEV RNA. The nucleotide sequences of these swine HEV strains shared 85% 99% identities with the local human genotype 4 isolates and belonged to two subgroups of genotype 4. Importantly, swine HEV strains representing both subgroups induced hepatitis in rhesus monkeys by inoculation with the virus, evidenced by elevated serum alanine transaminase (ALT), viremia, fecal viral shedding, anti-HEV seroconversion, and liver histopathological changes. Conclusions. Swine may be the principal reservoir for human HEV infection in rural southern China.

语种: 英语
WOS记录号: WOS:000258159500009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51409
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Liuzhou Med Coll, Liuzhou 545000, Guangxi Prov, Peoples R China
2.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Ji, Yanli,Zhu, Yonghong,Liang, Jingrui,et al. Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta)[J]. JOURNAL OF GASTROENTEROLOGY,2008,43(7):565-570.
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