|Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study|
|Li, Zhiwen1,2; Ye, Rongwei1,2; Zhang, Le1,2; Li, Hongtian1,2; Liu, Jianmeng1,2; Ren, Aiguo1,2|
|关键词||Folic Acid Periconceptional Supplementation Spontaneous Preterm Birth Preterm Premature Rupture Of Membranes Iatrogenic Preterm Birth Cohort Study|
|刊名||INTERNATIONAL JOURNAL OF EPIDEMIOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||GESTATIONAL-AGE BIRTHS ; NEURAL-TUBE DEFECTS ; MULTIVITAMIN USE ; SYSTEMATIC ANALYSIS ; TIME TRENDS ; PREGNANCY ; WEIGHT ; PREVENTION ; COUNTRIES ; DELIVERY|
Background: Folic acid-containing multivitamins have been associated with a reduced risk of preterm birth. We examined whether periconceptional use of folic acid alone reduced this risk.
Methods: Data were derived from a large population-based cohort study conducted in China to evaluate the prevention of neural tube defects with folic acid supplementation. The sample comprised 207 936 singleton live births delivered at gestational ages of 20-42 weeks to women from two provinces in southern China. Healthcare workers recorded folic acid intake prospectively each month. Gestational age calculation was based on the first day of the last menstrual period. Preterm births were categorized into three clinical subtypes: iatrogenic preterm birth, preterm premature rupture of membranes (PPROM) and spontaneous preterm birth. Logistic regression was used to evaluate the association between folic acid use and the risk of preterm birth, adjusting for potential confounders.
Results: The incidence of preterm birth was significantly lower among folic acid users (5.28%) than among non-users (6.10%). Folic acid use showed a 14% risk reduction for preterm birth overall [adjusted risk ratio (RR) = 0.86, 95% confidence interval (CI) 0.82-0.90]. This association was strongest for spontaneous preterm birth (adjusted RR = 0.81, 95% CI 0.78-0.86) and was not significant for iatrogenic preterm birth (adjusted RR = 0.97, 95% CI 0.88-1.07) or PPROM (adjusted RR = 1.07, 95% CI 0.93-1.23).
Conclusions: Daily intake of 400 lg folic acid alone during the periconceptional period was associated with a reduced risk of spontaneous preterm birth.
|项目编号||81373014 ; U01 DD000293 ; U01 DD000293|
|资助机构||National Natural Science Foundation of China ; US Centers for Disease Control and Prevention ; Peking University|
|作者单位||1.Minist Hlth, Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Beijing, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
|Li, Zhiwen,Ye, Rongwei,Zhang, Le,et al. Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2014,43(4):1132-1139.|
|APA||Li, Zhiwen,Ye, Rongwei,Zhang, Le,Li, Hongtian,Liu, Jianmeng,&Ren, Aiguo.(2014).Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,43(4),1132-1139.|
|MLA||Li, Zhiwen,et al."Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 43.4(2014):1132-1139.|