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Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study
Li, Zhiwen1,2; Ye, Rongwei1,2; Zhang, Le1,2; Li, Hongtian1,2; Liu, Jianmeng1,2; Ren, Aiguo1,2
关键词Folic Acid Periconceptional Supplementation Spontaneous Preterm Birth Preterm Premature Rupture Of Membranes Iatrogenic Preterm Birth Cohort Study
刊名INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
2014-08-01
DOI10.1093/ije/dyu020
43期:4页:1132-1139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]GESTATIONAL-AGE BIRTHS ; NEURAL-TUBE DEFECTS ; MULTIVITAMIN USE ; SYSTEMATIC ANALYSIS ; TIME TRENDS ; PREGNANCY ; WEIGHT ; PREVENTION ; COUNTRIES ; DELIVERY
英文摘要

Background: Folic acid-containing multivitamins have been associated with a reduced risk of preterm birth. We examined whether periconceptional use of folic acid alone reduced this risk.

Methods: Data were derived from a large population-based cohort study conducted in China to evaluate the prevention of neural tube defects with folic acid supplementation. The sample comprised 207 936 singleton live births delivered at gestational ages of 20-42 weeks to women from two provinces in southern China. Healthcare workers recorded folic acid intake prospectively each month. Gestational age calculation was based on the first day of the last menstrual period. Preterm births were categorized into three clinical subtypes: iatrogenic preterm birth, preterm premature rupture of membranes (PPROM) and spontaneous preterm birth. Logistic regression was used to evaluate the association between folic acid use and the risk of preterm birth, adjusting for potential confounders.

Results: The incidence of preterm birth was significantly lower among folic acid users (5.28%) than among non-users (6.10%). Folic acid use showed a 14% risk reduction for preterm birth overall [adjusted risk ratio (RR) = 0.86, 95% confidence interval (CI) 0.82-0.90]. This association was strongest for spontaneous preterm birth (adjusted RR = 0.81, 95% CI 0.78-0.86) and was not significant for iatrogenic preterm birth (adjusted RR = 0.97, 95% CI 0.88-1.07) or PPROM (adjusted RR = 1.07, 95% CI 0.93-1.23).

Conclusions: Daily intake of 400 lg folic acid alone during the periconceptional period was associated with a reduced risk of spontaneous preterm birth.

语种英语
WOS记录号WOS:000343935200020
项目编号81373014 ; U01 DD000293 ; U01 DD000293
资助机构National Natural Science Foundation of China ; US Centers for Disease Control and Prevention ; Peking University
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51420
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学公共卫生学院_卫计委生育健康重点实验室
作者单位1.Minist Hlth, Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Zhiwen,Ye, Rongwei,Zhang, Le,et al. Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2014,43(4):1132-1139.
APA Li, Zhiwen,Ye, Rongwei,Zhang, Le,Li, Hongtian,Liu, Jianmeng,&Ren, Aiguo.(2014).Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,43(4),1132-1139.
MLA Li, Zhiwen,et al."Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 43.4(2014):1132-1139.
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