IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
microRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma
Liu, Cuiling1,2; Iqbal, Javeed1; Teruya-Feldstein, Julie3; Shen, Yulei1; Dabrowska, Magdalena Julia4; Dybkaer, Karen4; Lim, Megan S.5; Piva, Roberto6,7; Barreca, Antonella6,7; Pellegrino, Elisa6,7; Spaccarotella, Elisa6,7; Lachel, Cynthia M.1; Kucuk, Can1; Jiang, Chun-Sun1; Hu, Xiaozhou1; Bhagavathi, Sharathkumar1; Greiner, Timothy C.1; Weisenburger, Dennis D.1; Aoun, Patricia1; Perkins, Sherrie L.8; McKeithan, Timothy W.1; Inghirami, Giorgio6,7; Chan, Wing C.1
刊名BLOOD
2013-09-19
DOI10.1182/blood-2012-08-447375
122期:12页:2083-2092
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
资助者National Cancer Institute ; National Cancer Institute
研究领域[WOS]Hematology
关键词[WOS]PERIPHERAL T-CELL ; GENE-EXPRESSION ; DOWN-REGULATION ; POOR-PROGNOSIS ; TUMOR-GROWTH ; ALK ; KINASE ; REVEALS ; ONCOGENE ; TARGET
英文摘要

Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[1]) ALCLs, 25 ALK-negative (ALK[2]) ALCLs, 9 angioimmunoblastic T-cell lymphomas, 11 peripheral T-cell lymphomas not otherwise specified (PTCLNOS), and normal T cells, and demonstrated that ALCLs express many of the miRNAs that are highly expressed in normal T cells with the prominent exception of miR-146a. Unsupervised hierarchical clustering demonstrated distinct clustering of ALCL, PTCL-NOS, and the AITL subtype of PTCL. Cases of ALK(1) ALCL and ALK(-) ALCL were interspersed in unsupervised analysis, suggesting a close relationship at the molecular level. We identified an miRNA signature of 7 miRNAs (5 upregulated: miR-512-3p, miR-886-5p, miR-886-3p, miR-708, miR-135b; 2 downregulated: miR-146a, miR-155) significantly associated with ALK(1) ALCL cases. In addition, we derived an 11-miRNA signature (4 upregulated: miR-210, miR-197, miR-191, miR-512-3p; 7 downregulated: miR-451, miR-146a, miR-22, miR-455-3p, miR-455-5p, miR-143, miR-494) that differentiates ALK(-) ALCL from other PTCLs. Our in vitro studies identified a set of 32 miRNAs associated with ALK expression. Of these, themiR-17 similar to 92 cluster and its paralogues were also highly expressed in ALK(1) ALCL and may represent important downstream effectors of the ALK oncogenic pathway.

语种英语
所属项目编号5U01/CA114778
资助者National Cancer Institute ; National Cancer Institute
WOS记录号WOS:000324854800018
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51427
Collection北京大学基础医学院_病理学系
作者单位1.Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy
2.Univ Turin, Ctr Expt Res & Med Studies, Turin, Italy
3.Univ Utah, Dept Pathol, Salt Lake City, UT USA
4.Univ Aarhus, Aalborg Hosp, Dept Hematol, Aarhus, Denmark
5.Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA
6.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
7.Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
8.Univ Michigan Hlth Syst, Dept Pathol, Ann Arbor, MI USA
Recommended Citation
GB/T 7714
Liu, Cuiling,Iqbal, Javeed,Teruya-Feldstein, Julie,et al. microRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma[J]. BLOOD,2013,122(12):2083-2092.
APA Liu, Cuiling.,Iqbal, Javeed.,Teruya-Feldstein, Julie.,Shen, Yulei.,Dabrowska, Magdalena Julia.,...&Chan, Wing C..(2013).microRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.BLOOD,122(12),2083-2092.
MLA Liu, Cuiling,et al."microRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma".BLOOD 122.12(2013):2083-2092.
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