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Using remote ischemic conditioning to reduce acute kidney injury in patients undergoing percutaneous coronary intervention: a meta-analysis
Zuo, Bo1,2; Wang, Fuhua1,2; Song, Zhu1,2; Xu, Ming3,4; Wang, Guisong1,2
关键词Acute Kidney Injury Complication Meta-analysis Percutaneous Coronary Intervention Remote Ischemic Conditioning
刊名CURRENT MEDICAL RESEARCH AND OPINION
2015-09-01
DOI10.1185/03007995.2015.1066766
31期:9页:1677-1685
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIALS ; CLINICAL-APPLICATION ; STENT IMPLANTATION ; MYOCARDIAL INJURY ; CARDIAC-SURGERY ; RENAL INJURY ; PRIMARY PCI ; PROTECTION ; DISEASE ; REPERFUSION
英文摘要

Background and aims:

It remains uncertain whether remote ischemic conditioning (RIC) could prevent acute kidney injury (AKI) in patients undergoing percutaneous coronary intervention (PCI). Thus, this meta-analysis aiming to explore the renoprotective role of RIC in patients undergoing PCI was carried out.

Methods:

PubMed, Web of Science, and Cochrane Library were searched from inception to 31 December 2014 to identify eligible randomized controlled trials. Pooled risk ratio, mean, standard deviation and 95% CI were used to assess the effect by fixed-or random-effect models. Heterogeneity was assessed by the Cochran Q and I-2 statistics.

Results:

Nine trials were included in this study. RIC decreased the AKI incidence in patients undergoing PCI compared with control individuals (P<0.001; RR, 0.53; 95% CI, 0.39-0.71; P for heterogeneity = 0.15; heterogeneity chi(2) = 13.38; I-2 = 33%). Besides, limb conditioning attenuated AKI (P = 0.001; RR, 0.57; 95% CI, 0.41-0.81; P for heterogeneity = 0.13; heterogeneity chi(2) = 12.48; I-2 = 36%). Remote postconditioning may reduce the AKI incidence (P = 0.03; RR, 0.65; 95% CI, 0.44-0.97; P for heterogeneity = 0.15; heterogeneity chi(2) = 5.36; I-2 = 44%); remote preconditioning could also play a renoprotective role (P<0.001; RR, 0.42; 95% CI, 0.27-0.65; P for heterogeneity = 0.31; heterogeneity chi(2) = 5.98; I-2 = 16%).

Conclusions:

RIC may not only confer cardioprotection, but also reduce the incidence of AKI in patients undergoing PCI, ultimately leading to better clinical outcomes. RIC may potentially be a powerful approach conferring protection in patients undergoing PCI in future clinical practice. More large-scale trials are required to obtain a more reliable conclusion.

语种英语
WOS记录号WOS:000361328000006
项目编号81170179
资助机构National Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51428
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China
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GB/T 7714
Zuo, Bo,Wang, Fuhua,Song, Zhu,et al. Using remote ischemic conditioning to reduce acute kidney injury in patients undergoing percutaneous coronary intervention: a meta-analysis[J]. CURRENT MEDICAL RESEARCH AND OPINION,2015,31(9):1677-1685.
APA Zuo, Bo,Wang, Fuhua,Song, Zhu,Xu, Ming,&Wang, Guisong.(2015).Using remote ischemic conditioning to reduce acute kidney injury in patients undergoing percutaneous coronary intervention: a meta-analysis.CURRENT MEDICAL RESEARCH AND OPINION,31(9),1677-1685.
MLA Zuo, Bo,et al."Using remote ischemic conditioning to reduce acute kidney injury in patients undergoing percutaneous coronary intervention: a meta-analysis".CURRENT MEDICAL RESEARCH AND OPINION 31.9(2015):1677-1685.
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