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学科主题: 临床医学
题名:
Using remote ischemic conditioning to reduce acute kidney injury in patients undergoing percutaneous coronary intervention: a meta-analysis
作者: Zuo, Bo1,2; Wang, Fuhua1,2; Song, Zhu1,2; Xu, Ming3,4; Wang, Guisong1,2
关键词: Acute kidney injury ; Complication ; Meta-analysis ; Percutaneous coronary intervention ; Remote ischemic conditioning
刊名: CURRENT MEDICAL RESEARCH AND OPINION
发表日期: 2015-09-01
DOI: 10.1185/03007995.2015.1066766
卷: 31, 期:9, 页:1677-1685
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]: General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]: RANDOMIZED CONTROLLED-TRIALS ; CLINICAL-APPLICATION ; STENT IMPLANTATION ; MYOCARDIAL INJURY ; CARDIAC-SURGERY ; RENAL INJURY ; PRIMARY PCI ; PROTECTION ; DISEASE ; REPERFUSION
英文摘要:

Background and aims:

It remains uncertain whether remote ischemic conditioning (RIC) could prevent acute kidney injury (AKI) in patients undergoing percutaneous coronary intervention (PCI). Thus, this meta-analysis aiming to explore the renoprotective role of RIC in patients undergoing PCI was carried out.

Methods:

PubMed, Web of Science, and Cochrane Library were searched from inception to 31 December 2014 to identify eligible randomized controlled trials. Pooled risk ratio, mean, standard deviation and 95% CI were used to assess the effect by fixed-or random-effect models. Heterogeneity was assessed by the Cochran Q and I-2 statistics.

Results:

Nine trials were included in this study. RIC decreased the AKI incidence in patients undergoing PCI compared with control individuals (P<0.001; RR, 0.53; 95% CI, 0.39-0.71; P for heterogeneity = 0.15; heterogeneity chi(2) = 13.38; I-2 = 33%). Besides, limb conditioning attenuated AKI (P = 0.001; RR, 0.57; 95% CI, 0.41-0.81; P for heterogeneity = 0.13; heterogeneity chi(2) = 12.48; I-2 = 36%). Remote postconditioning may reduce the AKI incidence (P = 0.03; RR, 0.65; 95% CI, 0.44-0.97; P for heterogeneity = 0.15; heterogeneity chi(2) = 5.36; I-2 = 44%); remote preconditioning could also play a renoprotective role (P<0.001; RR, 0.42; 95% CI, 0.27-0.65; P for heterogeneity = 0.31; heterogeneity chi(2) = 5.98; I-2 = 16%).

Conclusions:

RIC may not only confer cardioprotection, but also reduce the incidence of AKI in patients undergoing PCI, ultimately leading to better clinical outcomes. RIC may potentially be a powerful approach conferring protection in patients undergoing PCI in future clinical practice. More large-scale trials are required to obtain a more reliable conclusion.

语种: 英语
所属项目编号: 81170179
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000361328000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51428
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China

Recommended Citation:
Zuo, Bo,Wang, Fuhua,Song, Zhu,et al. Using remote ischemic conditioning to reduce acute kidney injury in patients undergoing percutaneous coronary intervention: a meta-analysis[J]. CURRENT MEDICAL RESEARCH AND OPINION,2015,31(9):1677-1685.
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