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学科主题基础医学
Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility
Zheng, M; Hou, R; Xiao, RP
关键词Mitogen-activated Protein Kinases Myocardium Ischemia Acidosis Contractility
刊名ACTA PHARMACOLOGICA SINICA
2004-10-01
25期:10页:1299-1305
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]N-TERMINAL KINASES ; PROTEIN-KINASE ; INTRACELLULAR ACIDIFICATION ; VENTRICULAR MYOCYTES ; ENERGY-STATE ; RAT HEARTS ; APOPTOSIS ; ISCHEMIA ; PH ; ALKALINIZATION
英文摘要

AIM: To determine the possible role of pH in mediating activation of p38 mitogen-activated protein kinase (MAPK) and the consequent function of activated p38 MAPK in regulating cardiac contractility. METHODS: Adult rat cardiomyocytes were isolated and cultured. Low pH media was used to induce intracellular acidosis and contraction of single cardiomyocyte was measured. RESULTS: Phosphorylation of p38 MAPK was increased during ischemia, and pH(i) was decreased. Intracellular acidosis activated p38 MAPK to a similar level as ischemia. Inhibition of p38 MAPK activation by SB203580, a specific inhibitor of p38 MAPK, reversed acidosis-mediated reduction of myocyte contractility. CONCLUSION: In adult rat cardiomyocytes, intracellular acidification activated p38 MAPK and decreased cardiac contractility. Pretreatment of cardiomyocytes with SB203580 completely blocked p38 MAPK activation and partially reversed acidosis-mediated decline of cardiac contractility.

语种英语
WOS记录号WOS:000224505800009
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51434
专题基础医学院_心血管所
作者单位Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
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GB/T 7714
Zheng, M,Hou, R,Xiao, RP. Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility[J]. ACTA PHARMACOLOGICA SINICA,2004,25(10):1299-1305.
APA Zheng, M,Hou, R,&Xiao, RP.(2004).Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility.ACTA PHARMACOLOGICA SINICA,25(10),1299-1305.
MLA Zheng, M,et al."Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility".ACTA PHARMACOLOGICA SINICA 25.10(2004):1299-1305.
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