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学科主题: 基础医学
题名:
Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility
作者: Zheng, M; Hou, R; Xiao, RP
关键词: mitogen-activated protein kinases ; myocardium ; ischemia ; acidosis ; contractility
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-10-01
卷: 25, 期:10, 页:1299-1305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: N-TERMINAL KINASES ; PROTEIN-KINASE ; INTRACELLULAR ACIDIFICATION ; VENTRICULAR MYOCYTES ; ENERGY-STATE ; RAT HEARTS ; APOPTOSIS ; ISCHEMIA ; PH ; ALKALINIZATION
英文摘要:

AIM: To determine the possible role of pH in mediating activation of p38 mitogen-activated protein kinase (MAPK) and the consequent function of activated p38 MAPK in regulating cardiac contractility. METHODS: Adult rat cardiomyocytes were isolated and cultured. Low pH media was used to induce intracellular acidosis and contraction of single cardiomyocyte was measured. RESULTS: Phosphorylation of p38 MAPK was increased during ischemia, and pH(i) was decreased. Intracellular acidosis activated p38 MAPK to a similar level as ischemia. Inhibition of p38 MAPK activation by SB203580, a specific inhibitor of p38 MAPK, reversed acidosis-mediated reduction of myocyte contractility. CONCLUSION: In adult rat cardiomyocytes, intracellular acidification activated p38 MAPK and decreased cardiac contractility. Pretreatment of cardiomyocytes with SB203580 completely blocked p38 MAPK activation and partially reversed acidosis-mediated decline of cardiac contractility.

语种: 英语
WOS记录号: WOS:000224505800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51434
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zheng, M,Hou, R,Xiao, RP. Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility[J]. ACTA PHARMACOLOGICA SINICA,2004,25(10):1299-1305.
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