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学科主题: 临床医学
题名:
LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China
作者: Cao, BW1; Tian, XY1; Li, Y1; Jiang, PW1; Ning, T1; Xing, HP1; Zhao, YQ1; Zhang, CF1; Shi, XT1; Chen, DF1; Shen, Y1; Ke, Y1
刊名: CARCINOGENESIS
发表日期: 2005-07-01
DOI: 10.1093/carcin/bgi071
卷: 26, 期:7, 页:1280-1284
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS ; CERVICAL-CANCER ; TAP POLYMORPHISM ; TRANSPORTER ; TRANSLOCATION ; EXPRESSION ; INTERFERON ; PROTEASOME ; VARIANTS ; PEPTIDES
英文摘要:

Esophageal carcinoma is characterized by a widely ranged incidence variation among the different geographic regions. Anyang is a county in Henan Province of North China with the highest prevalence of esophageal carcinoma. Human papillomavirus (HPV) infection has been linked to the etiology of esophageal cancer in this area. In this study, we investigated correlations of the polymorphisms at low molecular weight polypeptide (LMP) and transporters with antigen processing (TAP) genes, with the risk of esophageal carcinoma. DNA extracted from either tumor specimens or esophageal epithelial cells was used to test HPV infection. Peripheral blood lymphocyte DNA was used for LMP/TAP genotyping. Polymerase chain reaction was performed to analyze HPV infection and LMP/TAP gene polymorphisms. The combined effect of LMP/TAP gene polymorphisms and HPV infection on esophageal carcinoma was analyzed by using unconditional logistic regression models. The TAP2 codons 379 isoleucine carriers and LMP7 codons 145 lysine carriers were found to be more susceptible to esophageal carcinoma (OR = 2.74, 95% CI 1.15-6.49, P = 0.023 for TAP2; OR = 2.19, 95% CI 1.09-4.37, P = 0.027 for LMP7). Patients carrying homozygous LMP7/TAP2 haplotype C, which contained the glutamine at LMP7 codons 145 and the isoleucine at TAP2 codons 379, were more prone to develop esophageal carcinoma (OR = 2.96,95 % CI = 1.13-7.81, P = 0.027). An additive effect on the risk of esophageal carcinoma development was found among individuals carrying LMP7/TAP2 haplotype C and infected by HPV (OR = 4.33, 95% CI = 2.53-7.42, P < 0.0001). LMP7/TAP2 haplotype C may act as the risk factor in esophageal carcinoma development and it may influence the tumorigenesis in HPV infected individuals.

语种: 英语
WOS记录号: WOS:000230648600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51437
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100069, Peoples R China
2.Xuzhou No 1 Peoples Hosp, Xuzhou 221002, Jiangsu Prov, Peoples R China
3.Anyang Tumor Hosp, Anyang City 455000, Henan Province, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Dept Genet, Beijing 100034, Peoples R China
5.Peking Univ, Dept Cell Biol & Human Genet, Beijing 100086, Peoples R China
6.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100069, Peoples R China
7.Peking Union Med Coll, Beijing 100069, Peoples R China

Recommended Citation:
Cao, BW,Tian, XY,Li, Y,et al. LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China[J]. CARCINOGENESIS,2005,26(7):1280-1284.
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