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学科主题临床医学
LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China
Cao, BW1; Tian, XY1; Li, Y1; Jiang, PW1; Ning, T1; Xing, HP1; Zhao, YQ1; Zhang, CF1; Shi, XT1; Chen, DF1; Shen, Y1; Ke, Y1
刊名CARCINOGENESIS
2005-07-01
DOI10.1093/carcin/bgi071
26期:7页:1280-1284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN-PAPILLOMAVIRUS ; CERVICAL-CANCER ; TAP POLYMORPHISM ; TRANSPORTER ; TRANSLOCATION ; EXPRESSION ; INTERFERON ; PROTEASOME ; VARIANTS ; PEPTIDES
英文摘要

Esophageal carcinoma is characterized by a widely ranged incidence variation among the different geographic regions. Anyang is a county in Henan Province of North China with the highest prevalence of esophageal carcinoma. Human papillomavirus (HPV) infection has been linked to the etiology of esophageal cancer in this area. In this study, we investigated correlations of the polymorphisms at low molecular weight polypeptide (LMP) and transporters with antigen processing (TAP) genes, with the risk of esophageal carcinoma. DNA extracted from either tumor specimens or esophageal epithelial cells was used to test HPV infection. Peripheral blood lymphocyte DNA was used for LMP/TAP genotyping. Polymerase chain reaction was performed to analyze HPV infection and LMP/TAP gene polymorphisms. The combined effect of LMP/TAP gene polymorphisms and HPV infection on esophageal carcinoma was analyzed by using unconditional logistic regression models. The TAP2 codons 379 isoleucine carriers and LMP7 codons 145 lysine carriers were found to be more susceptible to esophageal carcinoma (OR = 2.74, 95% CI 1.15-6.49, P = 0.023 for TAP2; OR = 2.19, 95% CI 1.09-4.37, P = 0.027 for LMP7). Patients carrying homozygous LMP7/TAP2 haplotype C, which contained the glutamine at LMP7 codons 145 and the isoleucine at TAP2 codons 379, were more prone to develop esophageal carcinoma (OR = 2.96,95 % CI = 1.13-7.81, P = 0.027). An additive effect on the risk of esophageal carcinoma development was found among individuals carrying LMP7/TAP2 haplotype C and infected by HPV (OR = 4.33, 95% CI = 2.53-7.42, P < 0.0001). LMP7/TAP2 haplotype C may act as the risk factor in esophageal carcinoma development and it may influence the tumorigenesis in HPV infected individuals.

语种英语
WOS记录号WOS:000230648600014
引用统计
被引频次:63[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51437
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Chinese Natl Human Genome Ctr, Beijing 100069, Peoples R China
2.Xuzhou No 1 Peoples Hosp, Xuzhou 221002, Jiangsu Prov, Peoples R China
3.Anyang Tumor Hosp, Anyang City 455000, Henan Province, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Dept Genet, Beijing 100034, Peoples R China
5.Peking Univ, Dept Cell Biol & Human Genet, Beijing 100086, Peoples R China
6.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100069, Peoples R China
7.Peking Union Med Coll, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Cao, BW,Tian, XY,Li, Y,et al. LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China[J]. CARCINOGENESIS,2005,26(7):1280-1284.
APA Cao, BW.,Tian, XY.,Li, Y.,Jiang, PW.,Ning, T.,...&Ke, Y.(2005).LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China.CARCINOGENESIS,26(7),1280-1284.
MLA Cao, BW,et al."LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China".CARCINOGENESIS 26.7(2005):1280-1284.
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