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学科主题: 临床医学
题名:
Outcome of intravitreal bevacizumab for idiopathic choroidal neovascularization in a Chinese population
作者: Qi, Hui-Jun; Li, Xiao-Xin; Tao, Yong
关键词: bevacizumab ; idiopathic choroidal neovascularization ; Chinese population
刊名: CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
发表日期: 2010-08-01
DOI: 10.3129/i10-019
卷: 45, 期:4, 页:381-385
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: MACULAR DEGENERATION ; TRANSPUPILLARY THERMOTHERAPY ; PHOTODYNAMIC THERAPY ; ANGIOID STREAKS ; YOUNG-PATIENTS ; CASE SERIES ; AGE ; AVASTIN ; VERTEPORFIN
英文摘要:

Objective: To assess the long-term visual and anatomical outcomes and safety of intravitreal injection of bevacizumab for idiopathic choroidal neovascularization (ICNV) in Chinese patients.

Design: Retrospective interventional case series.

Participants: Seventy-seven eyes of 77 patients with ICNV.

Methods: Patients were given intravitreal injection of bevacizumab (1.25 mg/0.05 mL) for ICNV between March 2006 and May 2008. Main outcome measures were changes in best-corrected visual acuity (BCVA), central foveal thickness, which was measured by optical coherence tomography, and fluorescein angiography findings.

Results: Mean follow-up was 14.3 (SD 2.4, range 10 similar to 20) months. Mean BCVA improved from 0.66 (SD 0.36) logMAR at baseline to 0.25 (SD 0.28) logMAR at final follow-up (p < 0.001). Sixty-one patients (79%) gained BCVA of >= 2 Snellen lines, and 1 eye (1%) lost BCVA of >= 2 Snellen lines. Mean central foveal thickness decreased from 365 (SD 124) mu m at baseline to 211 (SD 94) pm at final visit (p < 0.001). Sixty-two eyes (81%) needed reinjection. Both BCVA improvement and the change in central foveal thickness between the 1- time injection group and the multi-injections group were not statistically significant (p = 0.45 and p = 0.19, respectively). No significant ocular or systemic adverse effects were observed.

Conclusions: The long-term results suggest an encouraging efficacy and safety of intravitreal bevacizumab for ICNV in Chinese patients.

语种: 英语
所属项目编号: 2006BAI02B05 ; 30901639
项目资助者: Key Project Grant in the National Science &amp ; Technology Pillar Program ; National Natural Science Foundation of China (Beijing, China)
WOS记录号: WOS:000281463000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51438
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China

Recommended Citation:
Qi, Hui-Jun,Li, Xiao-Xin,Tao, Yong. Outcome of intravitreal bevacizumab for idiopathic choroidal neovascularization in a Chinese population[J]. CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE,2010,45(4):381-385.
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