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IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科  > 期刊论文
学科主题: 临床医学
题名:
Differentiation plasticity of human fetal articular chondrocytes
作者: Cui, Ying1; Wang, Hong1; Yu, Minjun1; Xu, Tianri1; Li, Xuepei1; Li, Lingsong1
刊名: OTOLARYNGOLOGY-HEAD AND NECK SURGERY
发表日期: 2006-07-01
DOI: 10.1016/j.otohns.2006.02.026
卷: 135, 期:1, 页:61-67
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Otorhinolaryngology ; Surgery
研究领域[WOS]: Otorhinolaryngology ; Surgery
关键词[WOS]: MESENCHYMAL STEM-CELLS ; PROGENITOR CELLS ; BONE-MARROW ; IDENTIFICATION ; BIOLOGY ; RAT
英文摘要:

OBJECTIVE: To test chondrogenic differentiation potential. we examined the differentiation plasticity of isolated human fetal articular chondrocytes (HFACs).

STUDY AND DESIGN SETTING: Culture-expanded human fetal articular chondrocytes (HFACs) were analyzed for chondrogenic, adipogenic, osteogenic capacity and neural differentiation ability in defined in vitro culture systems.

RESULTS: The different assays demonstrated that culture-expanded HFACs have potential to form cartilage in pellet mass culture, to form adipose cells, osteogenic cells, and neural cells in monolayer culture.

CONCLUSIONS: These results suggest that within human fetal articular cartilages there are MSC-like cells that exhibit differentiation plasticity that is comparable with that of BM-MSCs and they may be a new kind of seeding cells for head and neck cartilage reconstruction. (c) 2006 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

语种: 英语
WOS记录号: WOS:000238824500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51439
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Hlth & Sci Ctr, Beijing, Peoples R China

Recommended Citation:
Cui, Ying,Wang, Hong,Yu, Minjun,et al. Differentiation plasticity of human fetal articular chondrocytes[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY,2006,135(1):61-67.
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