IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科
学科主题临床医学
Differentiation plasticity of human fetal articular chondrocytes
Cui, Ying1; Wang, Hong1; Yu, Minjun1; Xu, Tianri1; Li, Xuepei1; Li, Lingsong1
刊名OTOLARYNGOLOGY-HEAD AND NECK SURGERY
2006-07-01
DOI10.1016/j.otohns.2006.02.026
135期:1页:61-67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Otorhinolaryngology ; Surgery
研究领域[WOS]Otorhinolaryngology ; Surgery
关键词[WOS]MESENCHYMAL STEM-CELLS ; PROGENITOR CELLS ; BONE-MARROW ; IDENTIFICATION ; BIOLOGY ; RAT
英文摘要

OBJECTIVE: To test chondrogenic differentiation potential. we examined the differentiation plasticity of isolated human fetal articular chondrocytes (HFACs).

STUDY AND DESIGN SETTING: Culture-expanded human fetal articular chondrocytes (HFACs) were analyzed for chondrogenic, adipogenic, osteogenic capacity and neural differentiation ability in defined in vitro culture systems.

RESULTS: The different assays demonstrated that culture-expanded HFACs have potential to form cartilage in pellet mass culture, to form adipose cells, osteogenic cells, and neural cells in monolayer culture.

CONCLUSIONS: These results suggest that within human fetal articular cartilages there are MSC-like cells that exhibit differentiation plasticity that is comparable with that of BM-MSCs and they may be a new kind of seeding cells for head and neck cartilage reconstruction. (c) 2006 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

语种英语
WOS记录号WOS:000238824500012
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51439
专题北京大学第三临床医学院_耳鼻喉科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Hlth & Sci Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cui, Ying,Wang, Hong,Yu, Minjun,et al. Differentiation plasticity of human fetal articular chondrocytes[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY,2006,135(1):61-67.
APA Cui, Ying,Wang, Hong,Yu, Minjun,Xu, Tianri,Li, Xuepei,&Li, Lingsong.(2006).Differentiation plasticity of human fetal articular chondrocytes.OTOLARYNGOLOGY-HEAD AND NECK SURGERY,135(1),61-67.
MLA Cui, Ying,et al."Differentiation plasticity of human fetal articular chondrocytes".OTOLARYNGOLOGY-HEAD AND NECK SURGERY 135.1(2006):61-67.
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