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学科主题基础医学
Danshensu Inhibits beta-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis
Lu, Haiyan3; Tian, Aiju1,2; Wu, Jimin1,2; Yang, Chengzhi1,2; Xing, Rui1,2; Jia, Pu3; Yang, Lingjian3; Zhang, Youyi1,2; Zheng, Xiaohui3; Li, Zijian1,2
关键词Danshensu Beta-adrenergic Receptor Cardiac Fibrosis P38 Mapk Reactive Oxygen Specy
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2014-06-01
37期:6页:961-967
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Changjiang Scholars and Innovative Research Team in University ; National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Changjiang Scholars and Innovative Research Team in University
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HEART-FAILURE ; ROS GENERATION ; NADPH OXIDASE ; P38 MAPK ; CELLS ; APOPTOSIS ; ACTIVATION ; HYPERTROPHY ; FIBROBLASTS ; ISOPROTERENOL
英文摘要

Danshensu, the effective ingredient of the plant Salvia miltiorrhiza (Danshen), has been widely used for treatment of cardiovascular diseases. Cardiac fibrosis is an important process in pathological cardiac remodeling and leads to heart failure. We investigated the effect of Danshensu on beta-adrenergic receptor (beta-AR)-mediated cardiac fibrosis and the involved signaling transduction. Danshensu inhibited cardiofibroblast proliferation and collagen I synthesis induced by isoproterenol (ISO), a selective beta-AR agonist. Phosphorylation of p38 mitogen-activated protein kinase (MAPK), which mediates ISO-induced cardiac fibrosis, was negatively regulated in this process. The negative regulation depended on the ISO inhibition of reactive oxygen species (ROS) production. Taken together, Danshensu may inhibit beta-AR-mediated cardiac fibrosis by negative regulation of ROS-p38 MAPK signaling.

语种英语
所属项目编号2011CB503903 ; 81030001 ; 81070078 ; 81270157 ; 7102158 ; IRT1174
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Changjiang Scholars and Innovative Research Team in University ; National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Changjiang Scholars and Innovative Research Team in University
WOS记录号WOS:000336559200012
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51442
专题基础医学院_心血管所
作者单位1.Peking Univ, Key Lab Mol Cardiovasc Sci, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Inst Vasc Med,Hosp 3,Minist Hlth,Minist Educ, Beijing 100191, Peoples R China
2.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
3.NW Univ Xian, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Peoples R China
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GB/T 7714
Lu, Haiyan,Tian, Aiju,Wu, Jimin,et al. Danshensu Inhibits beta-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2014,37(6):961-967.
APA Lu, Haiyan.,Tian, Aiju.,Wu, Jimin.,Yang, Chengzhi.,Xing, Rui.,...&Li, Zijian.(2014).Danshensu Inhibits beta-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis.BIOLOGICAL & PHARMACEUTICAL BULLETIN,37(6),961-967.
MLA Lu, Haiyan,et al."Danshensu Inhibits beta-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis".BIOLOGICAL & PHARMACEUTICAL BULLETIN 37.6(2014):961-967.
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