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学科主题: 基础医学
题名:
Danshensu Inhibits beta-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis
作者: Lu, Haiyan3; Tian, Aiju1,2; Wu, Jimin1,2; Yang, Chengzhi1,2; Xing, Rui1,2; Jia, Pu3; Yang, Lingjian3; Zhang, Youyi1,2; Zheng, Xiaohui3; Li, Zijian1,2
关键词: Danshensu ; beta-adrenergic receptor ; cardiac fibrosis ; p38 MAPK ; reactive oxygen specy
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2014-06-01
卷: 37, 期:6, 页:961-967
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HEART-FAILURE ; ROS GENERATION ; NADPH OXIDASE ; P38 MAPK ; CELLS ; APOPTOSIS ; ACTIVATION ; HYPERTROPHY ; FIBROBLASTS ; ISOPROTERENOL
英文摘要:

Danshensu, the effective ingredient of the plant Salvia miltiorrhiza (Danshen), has been widely used for treatment of cardiovascular diseases. Cardiac fibrosis is an important process in pathological cardiac remodeling and leads to heart failure. We investigated the effect of Danshensu on beta-adrenergic receptor (beta-AR)-mediated cardiac fibrosis and the involved signaling transduction. Danshensu inhibited cardiofibroblast proliferation and collagen I synthesis induced by isoproterenol (ISO), a selective beta-AR agonist. Phosphorylation of p38 mitogen-activated protein kinase (MAPK), which mediates ISO-induced cardiac fibrosis, was negatively regulated in this process. The negative regulation depended on the ISO inhibition of reactive oxygen species (ROS) production. Taken together, Danshensu may inhibit beta-AR-mediated cardiac fibrosis by negative regulation of ROS-p38 MAPK signaling.

语种: 英语
所属项目编号: 2011CB503903 ; 81030001 ; 81070078 ; 81270157 ; 7102158 ; IRT1174
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Changjiang Scholars and Innovative Research Team in University
WOS记录号: WOS:000336559200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51442
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Key Lab Mol Cardiovasc Sci, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Inst Vasc Med,Hosp 3,Minist Hlth,Minist Educ, Beijing 100191, Peoples R China
2.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
3.NW Univ Xian, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Peoples R China

Recommended Citation:
Lu, Haiyan,Tian, Aiju,Wu, Jimin,et al. Danshensu Inhibits beta-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2014,37(6):961-967.
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