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学科主题: 公共卫生
题名:
Association of genetic polymorphisms with response to bevacizumab for neovascular age-related macular degeneration in the Chinese population
作者: Tian, Jun1; Qin, Xueying1; Fang, Kai1; Chen, Qing2; Hou, Jing3,4; Li, Juan5; Yu, Wenzhen3,4; Chen, Dafang1; Hu, Yonghua1; Li, Xiaoxin3,4
关键词: ARMS2 ; bevacizumab ; CFH ; HTRA1 ; neovascular age-related ; macular degeneration ; pharmacogenetics
刊名: PHARMACOGENOMICS
发表日期: 2012-05-01
DOI: 10.2217/PGS.12.53
卷: 13, 期:7, 页:779-787
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: COMPLEMENT FACTOR-H ; ENDOTHELIAL GROWTH-FACTOR ; HTRA1 PROMOTER POLYMORPHISM ; INTRAVITREAL BEVACIZUMAB ; RISK ; RANIBIZUMAB ; VARIANT ; MULTICENTER ; SERPING1 ; SMOKING
英文摘要:

Aims: To determine whether there is an association between CFH, ARMS2, HTRA1, VEGF, SERPING1 or C3 genotypes and patient response to treatment with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD). Materials & methods: This was a multicenter prospective study. One hundred and forty four patients with neovascular AMD treated with bevacizumab were recruited from 13 centers. Twelve SNPs were genotyped using Sequenom. Visual acuity score (VAS), central retinal thickness and maximum thickness of lesion were measured at each visit. Results: For the CFH rs800292 polymorphism, mean VAS changes were 4.4, 8.7 and 15.5 letters in the CC, CT and TT genotype carriers (p = 0.009). For ARMS2 rs10490924, mean VAS changes were 3.6, 12.1 and 9.6 letters for the TT, TG and GG genotypes (p = 0.001). For HTRA1 rs11200638, mean VAS changes were 3.6, 12.3 and 9.6 letters for the AA, AG and GG genotypes (p < 0.001). Conclusion: CFH, ARMS2 and HTRA1 genotypes may influence patient response to treatment with intravitreal bevacizumab for neovascular AMD.

语种: 英语
所属项目编号: 2006BAI02B05
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China, Beijing, China
WOS记录号: WOS:000303694800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51444
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
3.Third Mil Med Univ, Prevent Med Coll, Dept Hyg Toxicol, Changqing, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
5.Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China

Recommended Citation:
Tian, Jun,Qin, Xueying,Fang, Kai,et al. Association of genetic polymorphisms with response to bevacizumab for neovascular age-related macular degeneration in the Chinese population[J]. PHARMACOGENOMICS,2012,13(7):779-787.
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