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Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials
Dong, Jia-Yi1; Wang, Peiyu2; He, Ka3,4; Qin, Li-Qiang1
关键词Isoflavones C-reactive Protein Postmenopausal Women Meta-analysis
刊名MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
2011-11-01
DOI10.1097/gme.0b013e31821bfa24
18期:11页:1256-1262
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]CORONARY-HEART-DISEASE ; HORMONE-REPLACEMENT THERAPY ; CARDIOVASCULAR RISK-FACTORS ; KAPPA-B ACTIVATION ; ENDOTHELIAL FUNCTION ; METABOLIC SYNDROME ; EQUOL PRODUCTION ; LDL CHOLESTEROL ; CLINICAL-TRIALS ; MARKERS
英文摘要

Strong evidence suggests that C-reactive protein (CRP) is a novel risk factor for cardiovascular disease. We aimed to examine the effect of soy isoflavones on circulating CRP concentrations in postmenopausal women by conducting a meta-analysis of randomized controlled trials. We performed a literature search using PubMed, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases in December 2010 for randomized controlled trials conducted in postmenopausal women, using soy foods with isoflavones or isoflavone extracts as treatment, and with a report of CRP change. A meta-analysis was performed using a fixed-effects model or a random-effects model to calculate the combined effect size. In addition, subgroup and metaregression analyses were carried out to examine the influences of study designs and participant characteristics on the effect estimates. A pooled analysis of 14 trials showed a slight, but not significant, reduction of 0.17 mg/L (95% CI, -0.38 to 0.04; P = 0.12) in CRP concentrations among postmenopausal women with soy isoflavone intervention compared with controls. No substantial heterogeneity was observed. Subgroup analyses showed that soy isoflavones significantly lowered CRP by 0.70 mg/L (95% CI, -1.17 to -0.23; P = 0.003) among women with baseline CRP concentrations greater than 2.2 mg/L. No significant changes in CRP were observed in the other subgroups. Metaregression analysis further revealed that baseline CRP was a potential effect modifier of isoflavone treatment in lowering CRP. The present meta-analysis found insufficient evidence that soy isoflavones significantly reduce CRP concentrations in postmenopausal women. However, soy isoflavones may produce a significant reduction in CRP among postmenopausal women with elevated CRP.

语种英语
WOS记录号WOS:000296605500019
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51445
专题北京大学公共卫生学院
北京大学药学院_药剂学系
作者单位1.Soochow Univ, Dept Nutr & Food Hyg, Sch Radiat Med & Publ Hlth, Suzhou 215123, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China
3.Univ N Carolina, Sch Med, Chapel Hill, NC USA
4.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA
推荐引用方式
GB/T 7714
Dong, Jia-Yi,Wang, Peiyu,He, Ka,et al. Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials[J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,2011,18(11):1256-1262.
APA Dong, Jia-Yi,Wang, Peiyu,He, Ka,&Qin, Li-Qiang.(2011).Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials.MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,18(11),1256-1262.
MLA Dong, Jia-Yi,et al."Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials".MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 18.11(2011):1256-1262.
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