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学科主题: 临床医学
题名:
Functional polymorphism in the EpCAM gene is associated with occurrence and advanced disease status of cervical cancer in Chinese population
作者: Hu, Min2; Jian, Lan1; Zhang, Liyuan3; Zheng, Jiang1; You, Yonghe1; Deng, Jieqiong1; Li, Hua4; Zhou, Yifeng1
关键词: Cervical cancer ; Molecular epidemiology ; EpCAM ; Polymorphism
刊名: MOLECULAR BIOLOGY REPORTS
发表日期: 2012-07-01
DOI: 10.1007/s11033-012-1560-9
卷: 39, 期:7, 页:7303-7309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CELL ADHESION MOLECULE ; EP-CAM ; BREAST-CANCER ; POTENTIAL TARGET ; ANTIGEN EPCAM ; LUNG-CANCER ; EXPRESSION ; CARCINOMA ; RISK ; OVEREXPRESSION
英文摘要:

The epithelial cell adhesion molecule (EpCAM) was originally identified as a tumor associated antigen, attributable to its high expression on rapidly proliferating tumors of epithelial origin. EpCAM plays vital roles in carcinogenesis, tumor progression and metastasis in most tumors. A non-synonymous polymorphism (rs1126497 C/T) was found in exon 3 of EpCAM, which cause a transition from 115 Met to 115 Thr. Another polymorphism (rs1421 A/G) in the 3′UTR causes loss of has-miR-1183 binding. We performed a multiple independent case-control analysis to assess the association between EpCAM genotypes and cervical cancer risk. Genotyping a total of 518 patients with cervical cancer and 723 control subjects in a Chinese population, we observed that the variant EpCAM genotypes (rs1126497 CT, and TT) were associated with substantially increased risk of cervical cancer. Compared with the rs1126497 CC genotype, CT genotype had a significantly increased risk of cervical cancer (Crude OR = 1.70; 95% CI = 1.33-2.20; adjusted OR = 1.72; 95% CI = 1.33-2.22), the TT carriers had a further increased risk of cervical cancer (Crude OR = 1.94; 95% CI = 1.01-3.72; adjusted OR = 1.96; 95%CI = 1.01-3.81), and there was a trend for an allele dose effect on risk of cervical cancer (P < 0.001). Moreover, the allele T increases the risk for invasive disease or metastatic disease, compared with C allele. However, there exists no significant difference in genotype frequencies of rs1421 A/G site between cases and controls (P = 0.798). These findings suggest that rs1126497 C/T polymorphism in EpCAM may be a genetic modifier for developing cervical cancer.

语种: 英语
所属项目编号: 81001278 ; 81072366 ; 81171895 ; SYS201052 ; 20101561 ; BK2011297 ; 2009B03
项目资助者: National Natural Scientific Foundation of China ; Suzhou Science and Technology Agency ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Priority Academic Program Development of Jiangsu Higher Education Institutions ; Jiangsu Provincial Natural Science Foundation of China ; Jiangsu Province&prime ; s Key Medical Department ; Beijing Nova Program
WOS记录号: WOS:000304404600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51448
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Soochow Univ, Coll Med, Lab Canc Mol Genet, Suzhou 215123, Peoples R China
2.Soochow Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Suzhou 215004, Peoples R China
3.Soochow Univ, Affiliated Hosp 2, Dept Radiotherapy & Oncol, Suzhou 215004, Peoples R China
4.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Hu, Min,Jian, Lan,Zhang, Liyuan,et al. Functional polymorphism in the EpCAM gene is associated with occurrence and advanced disease status of cervical cancer in Chinese population[J]. MOLECULAR BIOLOGY REPORTS,2012,39(7):7303-7309.
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