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学科主题: 基础医学
题名:
Aging-associated excess formaldehyde leads to spatial memory deficits
作者: Tong, Zhiqian1,5; Han, Chanshuai1,4; Luo, Wenhong2; Li, Hui2; Luo, Hongjun2; Qiang, Min1,4; Su, Tao1,4; Wu, Beibei1,4; Liu, Ying1; Yang, Xu3; Wan, You5; Cui, Dehua5; He, Rongqiao1,6
刊名: SCIENTIFIC REPORTS
发表日期: 2013-05-09
DOI: 10.1038/srep01807
卷: 3, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SENSITIVE AMINE OXIDASE ; DNA METHYLATION ; ALCOHOL-DEHYDROGENASE ; SYNAPTIC PLASTICITY ; RETINOIC ACID ; DEMETHYLATION ; CELLS ; MICE ; ADH3 ; AGE
英文摘要:

Recent studies show that formaldehyde participates in DNA demethylation/methylation cycle. Emerging evidence identifies that neuronal activity induces global DNA demethylation and re-methylation; and DNA methylation is a critical step for memory formation. These data suggest that endogenous formaldehyde may intrinsically link learning-responsive DNA methylation status and memory formation. Here, we report that during spatial memory formation process, spatial training induces an initial global DNA demethylation and subsequent re-methylation associated with hippocampal formaldehyde elevation then decline to baseline level in Sprague Dawley rats. Scavenging this elevated formaldehyde by formaldehyde-degrading enzyme (FDH), or enhancing DNA demethylation by a DNA demethylating agent, both led to spatial memory deficits by blocking DNA re-methylation in rats. Furthermore, we found that the normal adult rats intrahippocampally injected with excess formaldehyde can imitate the aged-related spatial memory deficits and global DNA methylation decline. These findings indicate that aging-associated excess formaldheyde contributes to cognitive decline during aging.

语种: 英语
所属项目编号: 2012CB911000 ; 2010CB912303 ; 2013CB531000 ; GJHZ1131 ; 20090460047 ; 2012T50144 ; NSFC 31171080 ; 30970695
项目资助者: 973-Project ; QCAS Biotechnology Fund ; Chinese Postdoctoral Fund ; Natural Scientific Foundation of China
WOS记录号: WOS:000318572400002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51450
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Shantou Univ, Coll Med, Cent Lab, Shantou 515041, Guangdong, Peoples R China
4.Huazhong Normal Univ, Lab Environm Sci, Wuhan 430079, Peoples R China
5.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China

Recommended Citation:
Tong, Zhiqian,Han, Chanshuai,Luo, Wenhong,et al. Aging-associated excess formaldehyde leads to spatial memory deficits[J]. SCIENTIFIC REPORTS,2013,3(5).
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