学科主题临床医学
A Comparative Study of Patients′ Attitudes Toward Clinical Research in the United States and Urban and Rural China
Wu, Elizabeth1; Wang, Tianyi2; Lin, Tammy2; Chen, Xisui2; Guan, Zhe2; Cao, Claudia2; Rao, Huiying3; Yang, Ming3; Feng, Bo3; Pui, Sandra1; Chan, Melvin1; Fu, Sherry1; Lin, Andy4; Wei, Lai3; Lok, Anna S.1
关键词Enrollment Informed Consent Safety Privacy Financial Incentives Cultural Differences
刊名CTS-Clinical and Translational Science
2015-04-01
DOI10.1111/cts.12254
8期:2页:123-131
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]INFORMED-CONSENT ; PATIENTS WILLINGNESS ; TRIALS ; PARTICIPATION ; RECRUITMENT ; BARRIERS ; CANCER ; HEALTH ; VIEWS ; ETHICS
英文摘要

As the number of clinical trials conducted in China increases, understanding Chinese attitudes toward clinical research is critical for designing effective and ethical studies. Two survey studies were conducted in 2012 and 2013 to compare patient attitudes toward clinical research and factors affecting research participation in the United States and urban and rural China. We surveyed 525 patients in 2012 (186 US, 186 urban, 153 rural China) and 690 patients in 2013 (412 US, 206 urban, 72 rural China). US patients were more likely to have no concerns regarding research participation than Chinese patients. Most common concerns of US patients were safety, privacy and confidentiality, and time required. Safety was a top concern for many Chinese. Chinese patients, particularly rural Chinese, were more concerned about the likelihood of self-benefit, and receiving free medical care and financial incentive had greater influence on their participation. Being informed of the freedom to choose whether to participate or to leave a study was less important to Chinese patients. Our study provides important insights into Chinese patients′ attitudes toward clinical research and the need to educate them about their rights. These findings help in designing cross-cultural clinical studies that maximize enrollment while upholding Western ethical standards.

语种英语
WOS记录号WOS:000353239900007
资助机构University of Michigan Health System-Peking University Health Science Center Joint Institute for Clinical and Translational Research ; Tuktawa Foundation ; University of Michigan Medical School ; Global REACH Program
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51457
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Univ Michigan, Sch Med, Ann Arbor, MI USA
2.Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA
3.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China
4.Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Wu, Elizabeth,Wang, Tianyi,Lin, Tammy,et al. A Comparative Study of Patients′ Attitudes Toward Clinical Research in the United States and Urban and Rural China[J]. CTS-Clinical and Translational Science,2015,8(2):123-131.
APA Wu, Elizabeth.,Wang, Tianyi.,Lin, Tammy.,Chen, Xisui.,Guan, Zhe.,...&Lok, Anna S..(2015).A Comparative Study of Patients′ Attitudes Toward Clinical Research in the United States and Urban and Rural China.CTS-Clinical and Translational Science,8(2),123-131.
MLA Wu, Elizabeth,et al."A Comparative Study of Patients′ Attitudes Toward Clinical Research in the United States and Urban and Rural China".CTS-Clinical and Translational Science 8.2(2015):123-131.
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