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学科主题: 临床医学
题名:
A Comparative Study of Patients′ Attitudes Toward Clinical Research in the United States and Urban and Rural China
作者: Wu, Elizabeth1; Wang, Tianyi2; Lin, Tammy2; Chen, Xisui2; Guan, Zhe2; Cao, Claudia2; Rao, Huiying3; Yang, Ming3; Feng, Bo3; Pui, Sandra1; Chan, Melvin1; Fu, Sherry1; Lin, Andy4; Wei, Lai3; Lok, Anna S.1
关键词: enrollment ; informed consent ; safety ; privacy ; financial incentives ; cultural differences
刊名: CTS-Clinical and Translational Science
发表日期: 2015-04-01
DOI: 10.1111/cts.12254
卷: 8, 期:2, 页:123-131
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: INFORMED-CONSENT ; PATIENTS WILLINGNESS ; TRIALS ; PARTICIPATION ; RECRUITMENT ; BARRIERS ; CANCER ; HEALTH ; VIEWS ; ETHICS
英文摘要:

As the number of clinical trials conducted in China increases, understanding Chinese attitudes toward clinical research is critical for designing effective and ethical studies. Two survey studies were conducted in 2012 and 2013 to compare patient attitudes toward clinical research and factors affecting research participation in the United States and urban and rural China. We surveyed 525 patients in 2012 (186 US, 186 urban, 153 rural China) and 690 patients in 2013 (412 US, 206 urban, 72 rural China). US patients were more likely to have no concerns regarding research participation than Chinese patients. Most common concerns of US patients were safety, privacy and confidentiality, and time required. Safety was a top concern for many Chinese. Chinese patients, particularly rural Chinese, were more concerned about the likelihood of self-benefit, and receiving free medical care and financial incentive had greater influence on their participation. Being informed of the freedom to choose whether to participate or to leave a study was less important to Chinese patients. Our study provides important insights into Chinese patients′ attitudes toward clinical research and the need to educate them about their rights. These findings help in designing cross-cultural clinical studies that maximize enrollment while upholding Western ethical standards.

语种: 英语
项目资助者: University of Michigan Health System-Peking University Health Science Center Joint Institute for Clinical and Translational Research ; Tuktawa Foundation ; University of Michigan Medical School ; Global REACH Program
WOS记录号: WOS:000353239900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51457
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Univ Michigan, Sch Med, Ann Arbor, MI USA
2.Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA
3.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China
4.Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA

Recommended Citation:
Wu, Elizabeth,Wang, Tianyi,Lin, Tammy,et al. A Comparative Study of Patients′ Attitudes Toward Clinical Research in the United States and Urban and Rural China[J]. CTS-Clinical and Translational Science,2015,8(2):123-131.
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