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学科主题: 临床医学
题名:
Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity
作者: Chen, CY1; Xing, GM1; Wang, JX1; Zhao, YL1; Li, B1; Tang, J1; Jia, G1; Wang, TC1; Sun, J1; Xing, L1; Yuan, H1; Gao, YX1; Meng, H1; Chen, Z1; Zhao, F1; Chai, ZF1; Fang, XH1
刊名: NANO LETTERS
发表日期: 2005-10-01
DOI: 10.1021/nl051624b
卷: 5, 期:10, 页:2050-2057
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: WATER-SOLUBLE METALLOFULLERENES ; MRI CONTRAST AGENTS ; IN-VIVO ; FULLERENE ; C-60 ; TUMOR ; CYCLOPHOSPHAMIDE ; CYTOTOXICITY ; DERIVATIVES ; DESIGN
英文摘要:

[Gd@C-82(OH)(22)](n) particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency (similar to 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C-82(OH)(22)](n) particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

语种: 英语
WOS记录号: WOS:000232623700038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51458
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Techniques, Beijing 100049, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Sch Publ Hlth, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Chen, CY,Xing, GM,Wang, JX,et al. Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity[J]. NANO LETTERS,2005,5(10):2050-2057.
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