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学科主题临床医学
Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity
Chen, CY1; Xing, GM1; Wang, JX1; Zhao, YL1; Li, B1; Tang, J1; Jia, G1; Wang, TC1; Sun, J1; Xing, L1; Yuan, H1; Gao, YX1; Meng, H1; Chen, Z1; Zhao, F1; Chai, ZF1; Fang, XH1
刊名NANO LETTERS
2005-10-01
DOI10.1021/nl051624b
5期:10页:2050-2057
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]WATER-SOLUBLE METALLOFULLERENES ; MRI CONTRAST AGENTS ; IN-VIVO ; FULLERENE ; C-60 ; TUMOR ; CYCLOPHOSPHAMIDE ; CYTOTOXICITY ; DERIVATIVES ; DESIGN
英文摘要

[Gd@C-82(OH)(22)](n) particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency (similar to 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C-82(OH)(22)](n) particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

语种英语
WOS记录号WOS:000232623700038
引用统计
被引频次:208[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51458
专题北京大学第三临床医学院
作者单位1.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Techniques, Beijing 100049, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Sch Publ Hlth, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Chen, CY,Xing, GM,Wang, JX,et al. Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity[J]. NANO LETTERS,2005,5(10):2050-2057.
APA Chen, CY.,Xing, GM.,Wang, JX.,Zhao, YL.,Li, B.,...&Fang, XH.(2005).Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity.NANO LETTERS,5(10),2050-2057.
MLA Chen, CY,et al."Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity".NANO LETTERS 5.10(2005):2050-2057.
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