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O-mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature
Zhou, Hui1; Hu, Hongyan2; Zhang, Lijuan3; Li, Ruoyu1; Ouyang, Haomiao1; Ming, Jia1; Jin, Cheng1
刊名EUKARYOTIC CELL
2007-12-01
DOI10.1128/EC.00261-07
6期:12页:2260-2268
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
研究领域[WOS]Microbiology
关键词[WOS]PROTEIN O-MANNOSYLTRANSFERASE ; CANDIDA-ALBICANS ; SACCHAROMYCES-CEREVISIAE ; MANNOSYL-TRANSFERASE ; GENE POMT1 ; GLYCOSYLATION ; NIDULANS ; YEAST ; FAMILY ; DROSOPHILA
英文摘要

Protein O-mannosyltransferases initiate 0 mannosylation of secretory proteins, which are of fundamental importance in eukaryotes. In this study, the PMT gene family of the human fungal pathogen Aspergillus fumigatus was identified and characterized. Unlike the case in Saccharomyces cerevisiae, where the PMT family is highly redundant, only one member of each PMT subfamily, namely, Afpmt1, Afpmt2, and Afpmt4, is present in A. fumigatus. Mutants with a deletion of Afpmt1 are viable. In vitro and in vivo activity assays confirmed that the protein encoded by Afpmt1 acts as an O-mannosyltransferase (AfPmt1p). Characterization of the Delta Afpm1 mutant showed that a lack of AfPmt1p results in sensitivity to elevated temperature and defects in growth and cell wall integrity, thereby affecting cell morphology, conidium formation, and germination. In a mouse model, Afpmt1 was not required for the virulence of A. fumigatus under the experimental conditions used.

语种英语
WOS记录号WOS:000251896100011
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51464
专题北京大学第一临床医学院
北京大学医学部管理机构_人事处
作者单位1.Gen Hosp Chinese People Armed Police Forces, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China
3.Peking Univ, Peking Univ Hosp 1, Res Med Ctr Mycol, Beijing 100034, Peoples R China
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GB/T 7714
Zhou, Hui,Hu, Hongyan,Zhang, Lijuan,et al. O-mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature[J]. EUKARYOTIC CELL,2007,6(12):2260-2268.
APA Zhou, Hui.,Hu, Hongyan.,Zhang, Lijuan.,Li, Ruoyu.,Ouyang, Haomiao.,...&Jin, Cheng.(2007).O-mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature.EUKARYOTIC CELL,6(12),2260-2268.
MLA Zhou, Hui,et al."O-mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature".EUKARYOTIC CELL 6.12(2007):2260-2268.
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