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学科主题: 临床医学
题名:
O-mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature
作者: Zhou, Hui1; Hu, Hongyan2; Zhang, Lijuan3; Li, Ruoyu1; Ouyang, Haomiao1; Ming, Jia1; Jin, Cheng1
刊名: EUKARYOTIC CELL
发表日期: 2007-12-01
DOI: 10.1128/EC.00261-07
卷: 6, 期:12, 页:2260-2268
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: PROTEIN O-MANNOSYLTRANSFERASE ; CANDIDA-ALBICANS ; SACCHAROMYCES-CEREVISIAE ; MANNOSYL-TRANSFERASE ; GENE POMT1 ; GLYCOSYLATION ; NIDULANS ; YEAST ; FAMILY ; DROSOPHILA
英文摘要:

Protein O-mannosyltransferases initiate 0 mannosylation of secretory proteins, which are of fundamental importance in eukaryotes. In this study, the PMT gene family of the human fungal pathogen Aspergillus fumigatus was identified and characterized. Unlike the case in Saccharomyces cerevisiae, where the PMT family is highly redundant, only one member of each PMT subfamily, namely, Afpmt1, Afpmt2, and Afpmt4, is present in A. fumigatus. Mutants with a deletion of Afpmt1 are viable. In vitro and in vivo activity assays confirmed that the protein encoded by Afpmt1 acts as an O-mannosyltransferase (AfPmt1p). Characterization of the Delta Afpm1 mutant showed that a lack of AfPmt1p results in sensitivity to elevated temperature and defects in growth and cell wall integrity, thereby affecting cell morphology, conidium formation, and germination. In a mouse model, Afpmt1 was not required for the virulence of A. fumigatus under the experimental conditions used.

语种: 英语
WOS记录号: WOS:000251896100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51464
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Gen Hosp Chinese People Armed Police Forces, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China
3.Peking Univ, Peking Univ Hosp 1, Res Med Ctr Mycol, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, Hui,Hu, Hongyan,Zhang, Lijuan,et al. O-mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature[J]. EUKARYOTIC CELL,2007,6(12):2260-2268.
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