|Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance|
|Sun, Hao-Ting1,2; Wen, Xin3; Han, Tian4; Liu, Zhen-Hua5,6; Li, Shao-Bo1; Wang, Ji-Gang1; Liu, Xiu-Ping7|
|关键词||Cytoplasmic Polyadenylation Element Binding Protein 4 Invasive Ductal Carcinoma Immunohistochemistry Prognosis|
|刊名||ONCOTARGETS AND THERAPY|
|WOS标题词||Science & Technology|
|类目[WOS]||Biotechnology & Applied Microbiology ; Oncology|
|研究领域[WOS]||Biotechnology & Applied Microbiology ; Oncology|
|关键词[WOS]||XENOPUS OOCYTE MATURATION ; GROWTH-FACTOR RECEPTOR ; CYTOPLASMIC POLYADENYLATION ; TRANSLATIONAL CONTROL ; CLINICAL-PRACTICE ; CANCER PATIENTS ; MESSENGER-RNA ; BETA-CATENIN ; MARKERS ; RECOMMENDATIONS|
Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.
Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.
Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P < 0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).
Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.
|作者单位||1.Peking Univ, Inst Urol, Hosp 1, Beijing 100871, Peoples R China|
2.Peking Univ, Urol Dept, Beijing 100871, Peoples R China
3.Fudan Univ, Sch Basic Med Sci, Dept Pathol, Shanghai 200240, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200240, Peoples R China
5.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Ctr Canc, Guangzhou, Guangdong, Peoples R China
6.Fudan Univ, Key Lab Myopia, Minist Hlth, Dept Ophthalmol,Eye & ENT Hosp, Shanghai 200240, Peoples R China
7.Fudan Univ, Peoples Hosp Shanghai 5, Dept Pathol, Shanghai 200240, Peoples R China
|Sun, Hao-Ting,Wen, Xin,Han, Tian,et al. Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance[J]. ONCOTARGETS AND THERAPY,2015,8:3499-3506.|
|APA||Sun, Hao-Ting.,Wen, Xin.,Han, Tian.,Liu, Zhen-Hua.,Li, Shao-Bo.,...&Liu, Xiu-Ping.(2015).Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.ONCOTARGETS AND THERAPY,8,3499-3506.|
|MLA||Sun, Hao-Ting,et al."Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance".ONCOTARGETS AND THERAPY 8(2015):3499-3506.|