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学科主题临床医学
Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance
Sun, Hao-Ting1,2; Wen, Xin3; Han, Tian4; Liu, Zhen-Hua5,6; Li, Shao-Bo1; Wang, Ji-Gang1; Liu, Xiu-Ping7
关键词Cytoplasmic Polyadenylation Element Binding Protein 4 Invasive Ductal Carcinoma Immunohistochemistry Prognosis
刊名ONCOTARGETS AND THERAPY
2015
DOI10.2147/OTT.S87587
8页:3499-3506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology
资助者National Natural Science Foundation of China ; Shanghai Natural Science Foundation ; Department of Pathology of Huashan Hospital ; National Natural Science Foundation of China ; Shanghai Natural Science Foundation ; Department of Pathology of Huashan Hospital
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]XENOPUS OOCYTE MATURATION ; GROWTH-FACTOR RECEPTOR ; CYTOPLASMIC POLYADENYLATION ; TRANSLATIONAL CONTROL ; CLINICAL-PRACTICE ; CANCER PATIENTS ; MESSENGER-RNA ; BETA-CATENIN ; MARKERS ; RECOMMENDATIONS
英文摘要

Aims: Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.

Methods: Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.

Results: High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P < 0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).

Conclusion: High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.

语种英语
所属项目编号81272387 ; 81470857 ; 81502272 ; 134119b1100
资助者National Natural Science Foundation of China ; Shanghai Natural Science Foundation ; Department of Pathology of Huashan Hospital ; National Natural Science Foundation of China ; Shanghai Natural Science Foundation ; Department of Pathology of Huashan Hospital
WOS记录号WOS:000366036800001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51470
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Inst Urol, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Urol Dept, Beijing 100871, Peoples R China
3.Fudan Univ, Sch Basic Med Sci, Dept Pathol, Shanghai 200240, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200240, Peoples R China
5.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Ctr Canc, Guangzhou, Guangdong, Peoples R China
6.Fudan Univ, Key Lab Myopia, Minist Hlth, Dept Ophthalmol,Eye & ENT Hosp, Shanghai 200240, Peoples R China
7.Fudan Univ, Peoples Hosp Shanghai 5, Dept Pathol, Shanghai 200240, Peoples R China
推荐引用方式
GB/T 7714
Sun, Hao-Ting,Wen, Xin,Han, Tian,et al. Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance[J]. ONCOTARGETS AND THERAPY,2015,8:3499-3506.
APA Sun, Hao-Ting.,Wen, Xin.,Han, Tian.,Liu, Zhen-Hua.,Li, Shao-Bo.,...&Liu, Xiu-Ping.(2015).Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.ONCOTARGETS AND THERAPY,8,3499-3506.
MLA Sun, Hao-Ting,et al."Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance".ONCOTARGETS AND THERAPY 8(2015):3499-3506.
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