IR@PKUHSC  > 北京大学基础医学院  > 医学信息学系
学科主题医学信息学
Identification and Characterization of Human snoRNA Core Promoters
Li, Tingting1,2; Zhou, Xueya3; Wang, Xiaowo3; Zhu, Dahai2; Zhang, Yong2
关键词Snornas Core Promoters Computation Transcriptional Models Transcriptional Regulation
刊名GENOMICS
2010-07-01
DOI10.1016/j.ygeno.2010.03.010
96期:1页:50-56
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Chinese National Programs for High Technology Research and Development ; National Basic Research Program of China ; National Natural Science Foundation of China ; Chinese National Programs for High Technology Research and Development
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]SMALL NUCLEOLAR RNAS ; PRE-MESSENGER-RNA ; GENOME-WIDE ANALYSIS ; BOX C/D ; TRANSCRIPTIONAL REGULATION ; MAMMALIAN-CELLS ; NONCODING RNAS ; POLYMERASE-III ; INTRON ; GENES
英文摘要

Small nucleolar RNAs (snoRNAs) represent one of the largest groups of functional non-protein coding RNAs currently known in eukaryotic cells. The processing of intron encoded snoRNAs has been well documented; however, the transcriptional regulation of snoRNA genes is still poorly understood, most likely due to the lack of characterization of snoRNA promoters. Here we used a computational approach to predict core promoters for 131 human snoRNAs. Majority of putative snoRNA promoters are supported by DNase I hypersensitivities, RNA polymerase II ChIP-seq peaks, or CAGE tag clusters. Based on the genomic organizations of predicted human snoRNA promoters, we propose five transcriptional models of those snoRNA genes; we also found evidence that some intronic human snoRNAs might have their own promoters. The present study is the first in silico screening of human snoRNAs promoters; and we anticipate the data will facilitate further molecular characterization of transcriptional control of human snoRNA genes. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2007CB946903 ; 2005CB522405 ; 2009CB941602 ; 2009CB825403 ; 30871248 ; 60905014 ; 2006AA10A121 ; 2007AA02Z109
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Chinese National Programs for High Technology Research and Development ; National Basic Research Program of China ; National Natural Science Foundation of China ; Chinese National Programs for High Technology Research and Development
WOS记录号WOS:000279305700006
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51476
Collection北京大学基础医学院_医学信息学系
作者单位1.Peking Univ Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Sch Basic Med, Peking Union Med Coll, Natl Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
3.Tsinghua Univ, Dept Automat, TNLIST, MOE Key Lab Bioinformat & Bioinformat Div, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Li, Tingting,Zhou, Xueya,Wang, Xiaowo,et al. Identification and Characterization of Human snoRNA Core Promoters[J]. GENOMICS,2010,96(1):50-56.
APA Li, Tingting,Zhou, Xueya,Wang, Xiaowo,Zhu, Dahai,&Zhang, Yong.(2010).Identification and Characterization of Human snoRNA Core Promoters.GENOMICS,96(1),50-56.
MLA Li, Tingting,et al."Identification and Characterization of Human snoRNA Core Promoters".GENOMICS 96.1(2010):50-56.
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