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学科主题: 基础医学
题名:
Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry
作者: OuYanga, Xiao-kun2; Chen, Xiao-hong1; Yan, Yong-qing3; Jin, Mi-cong1
关键词: ion chromatography-mass spectrometry ; chlorophacinone ; rodenticide ; plasma ; gradient eluent generator
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2009-05-01
DOI: 10.1002/bmc.1148
卷: 23, 期:5, 页:524-530
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; 8 ANTICOAGULANT RODENTICIDES ; SOLID-PHASE EXTRACTION ; LC-APCI-MS ; ANIMAL-TISSUES ; WHOLE-BLOOD ; MULTIRESIDUE ANALYSIS ; DIPHACINONE ; RESIDUES ; SERUM
英文摘要:

Plasmatic chlorophacinone is commonly measured with liquid chromatographic assay, which convenient but lacks sensitivity and selectivity and usually requires ion pair reagents to reduce the chromatographic tailed peak. In this paper, a novel method using eluent generator reagent-free ion chromatography coupled with electrospray ionization ion trap mass spectrometric detection for the determination of chlorophacinone in plasma has been developed. After samples were extracted with 10% (v/v) methanol in acetonitrile and cleaned by solid-phase extraction, chromatographic separation was performed on an lonPac (R) AS11 analytical column (250 x 4.0 mm) using 40.0 mmol/L KOH containing 10% (v/v) methanol as organic modifier. Quantification was performed by negative electrospray ionization in multiple reaction monitoring mode. The transition m/z 373 -> 201 was for the quantification ion; the transitions m/z 373 -> 172 and m/z 373 -> 145, as well as the isotope ions m/z 375 and m/z 203, were for the qualitative ions. All the method parameters were validated. It was confirmed that this method can be used in clinical diagnosis and forensic toxicology. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 2007A610072 ; 2007C10084 ; 2007QN014
项目资助者: Natural Science Foundation of Ningbo, China ; Agriculture and Social Development Funds of Ningbo, China ; Medical Health Youth Funds in Zhejiang Province, China
WOS记录号: WOS:000265435800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51480
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Ningbo Municipal Ctr Dis Control & Prevent, Ningbo 315010, Zhejiang, Peoples R China
3.Zhejiang Ocean Univ, Sch Food & Pharm, Zhoushan 316004, Peoples R China

Recommended Citation:
OuYanga, Xiao-kun,Chen, Xiao-hong,Yan, Yong-qing,et al. Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2009,23(5):524-530.
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