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学科主题基础医学
Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry
OuYanga, Xiao-kun2; Chen, Xiao-hong1; Yan, Yong-qing3; Jin, Mi-cong1
关键词Ion Chromatography-mass Spectrometry Chlorophacinone Rodenticide Plasma Gradient Eluent Generator
刊名BIOMEDICAL CHROMATOGRAPHY
2009-05-01
DOI10.1002/bmc.1148
23期:5页:524-530
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; 8 ANTICOAGULANT RODENTICIDES ; SOLID-PHASE EXTRACTION ; LC-APCI-MS ; ANIMAL-TISSUES ; WHOLE-BLOOD ; MULTIRESIDUE ANALYSIS ; DIPHACINONE ; RESIDUES ; SERUM
英文摘要

Plasmatic chlorophacinone is commonly measured with liquid chromatographic assay, which convenient but lacks sensitivity and selectivity and usually requires ion pair reagents to reduce the chromatographic tailed peak. In this paper, a novel method using eluent generator reagent-free ion chromatography coupled with electrospray ionization ion trap mass spectrometric detection for the determination of chlorophacinone in plasma has been developed. After samples were extracted with 10% (v/v) methanol in acetonitrile and cleaned by solid-phase extraction, chromatographic separation was performed on an lonPac (R) AS11 analytical column (250 x 4.0 mm) using 40.0 mmol/L KOH containing 10% (v/v) methanol as organic modifier. Quantification was performed by negative electrospray ionization in multiple reaction monitoring mode. The transition m/z 373 -> 201 was for the quantification ion; the transitions m/z 373 -> 172 and m/z 373 -> 145, as well as the isotope ions m/z 375 and m/z 203, were for the qualitative ions. All the method parameters were validated. It was confirmed that this method can be used in clinical diagnosis and forensic toxicology. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000265435800011
项目编号2007A610072 ; 2007C10084 ; 2007QN014
资助机构Natural Science Foundation of Ningbo, China ; Agriculture and Social Development Funds of Ningbo, China ; Medical Health Youth Funds in Zhejiang Province, China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51480
专题北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Ningbo Municipal Ctr Dis Control & Prevent, Ningbo 315010, Zhejiang, Peoples R China
3.Zhejiang Ocean Univ, Sch Food & Pharm, Zhoushan 316004, Peoples R China
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GB/T 7714
OuYanga, Xiao-kun,Chen, Xiao-hong,Yan, Yong-qing,et al. Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2009,23(5):524-530.
APA OuYanga, Xiao-kun,Chen, Xiao-hong,Yan, Yong-qing,&Jin, Mi-cong.(2009).Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry.BIOMEDICAL CHROMATOGRAPHY,23(5),524-530.
MLA OuYanga, Xiao-kun,et al."Characterization and determination of chlorophacinone in plasma by ion chromatography coupled with ion trap electrospray ionization mass spectrometry".BIOMEDICAL CHROMATOGRAPHY 23.5(2009):524-530.
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