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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction
作者: Chen, Shaomin1; Guo, Lijun1; Chen, Baoxia1; Sun, Lijie1; Cui, Ming1
关键词: acute myocardial infarction ; angiopoietin ; heart failure
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2013-03-01
DOI: 10.3892/etm.2013.893
卷: 5, 期:3, 页:937-941
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; PERCUTANEOUS CORONARY INTERVENTION ; RECEPTOR TIE-2 ; PLASMA ANGIOPOIETIN-1 ; DYNAMIC CHANGES ; INJURY ; RISK ; ANGIOGENESIS ; HYPERTENSION ; REPERFUSION
英文摘要:

The aim of the present study was to investigate the association of the serum angiopoietin (Ang)-1 and Ang-2 levels and the Ang-2 to Ang-1 ratio (Ang-2/Ang-1) with heart failure (HF) in patients with acute myocardial infarction (AMI) during hospitalization. The serum Ang-1 and Ang-2 levels of the AMI patients were measured at admission to hospital. The correlations between serum Ang-1, Ang-2 and Ang-2/Ang-1 with HF were examined. Among 103 patients, 20 developed HF during hospitalization. The serum Ang-2 level and Ang-2/Ang-1 were found to be significantly higher in the patients with HF than in the patients without HF (2,203.1 +/- 122.0 vs. 2,102.3 +/- 114.4 pg/ml, P=0.001 and 11.4 +/- 1.6x10(-2) vs. 10.6 +/- 1.1x10(-2), P=0.007, respectively). Serum Ang-2 level and Ang-2/Ang-1 were negatively correlated with left ventricular ejection fraction (LVEF; r=-0.352, P<0.001 and r=-0.365, P<0.001, respectively) and positively correlated with the natural logarithm of the level of N-terminal pro-B-type natriuretic peptide (LnNT-proBNP, r=0.367, P<0.001 and r=0.304, P=0.003, respectively) and peak cardiac troponin T (cTnT, r=0.421, P<0.001 and r=0.278, P=0.009, respectively). However, the serum Ang-1 level was not found to correlate significantly with LVEF (r=0.194, P=0.05), LnNT-proBNP (r=-0.116, P=0.266) or peak cTnT (r=-0.056, P=0.607). In multivariable logistic regression analysis, Ang-2 (P=0.031), Ang-2/Ang-1 (P=0.018) and NT-proBNP (P=0.001) were revealed to be independently associated with HF. The present study reveals that Ang-2 levels and Ang-2/Ang-1 are independent predictors of HF in AMI patients during hospitalization.

语种: 英语
所属项目编号: 81070260 ; 31070948 ; 7102099 ; 7122200
项目资助者: National Natural Sciences Foundation of China ; Beijing Natural Sciences Foundation
WOS记录号: WOS:000315423500052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51485
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Shaomin,Guo, Lijun,Chen, Baoxia,et al. Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2013,5(3):937-941.
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