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学科主题: 基础医学
题名:
Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast
作者: Ho, Y. W.1; Yeung, J. S. L.1; Chin, P. K. Y.1; Tang, W. M.1; Lin, Z. B.1; Man, R. Y. K.1; Lau, C. S.1
关键词: Ganoderma lucidum ; rheumatoid arthritis ; synovial fibroblast ; cytokines ; NF-kappa B ; inflammation
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2007-07-01
DOI: 10.1007/s11010-006-9409-y
卷: 301, 期:1-2, 页:173-179
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: INTERLEUKIN 6 ; ARTHRITIS ; CELLS ; BLOOD ; SYNOVIOCYTES ; MACROPHAGES ; EXPRESSION ; PREVENTION ; ANTIBODY ; TSUGAE
英文摘要:

The aim of the current study was to elucidate the potential therapeutic effect of Ganoderma lucidum polysaccharide peptide (GL-PP) in rheumatoid arthritis (RA). The effects of GL-PP on cell proliferation and cytokine production were studied in RA synovial fibroblasts (RASF). GL-PP significantly inhibited the proliferation of RASF. Following the incubation with GL-PP, production of interleukin (IL)6 and monocyte chemoattractant protein (MCP)-1 in RASF were significantly increased as expressed as percentage change from basal values. However, the actual effects were minimal due to the low basal values. When RASF were activated by IL-1 beta or lipopolysaccharides, IL-8 and MCP-1 production increased many folds. GL-PP significantly suppressed their productions. The inhibitory effects of GL-PP on cytokine production in RASF were at least in part, by inhibiting the nuclear factor-kappa B (NF-kappa B) transcription pathway. Our results demonstrated that GL-PP had the unique ability to modulate cytokine production in RASF and warrants further investigation into its mechanism of action.

语种: 英语
WOS记录号: WOS:000247679400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51487
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Univ Hong Kong, Dept Med, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Ho, Y. W.,Yeung, J. S. L.,Chin, P. K. Y.,et al. Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,301(1-2):173-179.
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