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学科主题基础医学
Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast
Ho, Y. W.1; Yeung, J. S. L.1; Chin, P. K. Y.1; Tang, W. M.1; Lin, Z. B.1; Man, R. Y. K.1; Lau, C. S.1
关键词Ganoderma Lucidum Rheumatoid Arthritis Synovial Fibroblast Cytokines Nf-kappa b Inflammation
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2007-07-01
DOI10.1007/s11010-006-9409-y
301期:1-2页:173-179
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]INTERLEUKIN 6 ; ARTHRITIS ; CELLS ; BLOOD ; SYNOVIOCYTES ; MACROPHAGES ; EXPRESSION ; PREVENTION ; ANTIBODY ; TSUGAE
英文摘要

The aim of the current study was to elucidate the potential therapeutic effect of Ganoderma lucidum polysaccharide peptide (GL-PP) in rheumatoid arthritis (RA). The effects of GL-PP on cell proliferation and cytokine production were studied in RA synovial fibroblasts (RASF). GL-PP significantly inhibited the proliferation of RASF. Following the incubation with GL-PP, production of interleukin (IL)6 and monocyte chemoattractant protein (MCP)-1 in RASF were significantly increased as expressed as percentage change from basal values. However, the actual effects were minimal due to the low basal values. When RASF were activated by IL-1 beta or lipopolysaccharides, IL-8 and MCP-1 production increased many folds. GL-PP significantly suppressed their productions. The inhibitory effects of GL-PP on cytokine production in RASF were at least in part, by inhibiting the nuclear factor-kappa B (NF-kappa B) transcription pathway. Our results demonstrated that GL-PP had the unique ability to modulate cytokine production in RASF and warrants further investigation into its mechanism of action.

语种英语
WOS记录号WOS:000247679400018
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51487
专题北京大学基础医学院_药理学系
作者单位1.Univ Hong Kong, Dept Med, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ho, Y. W.,Yeung, J. S. L.,Chin, P. K. Y.,et al. Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,301(1-2):173-179.
APA Ho, Y. W..,Yeung, J. S. L..,Chin, P. K. Y..,Tang, W. M..,Lin, Z. B..,...&Lau, C. S..(2007).Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast.MOLECULAR AND CELLULAR BIOCHEMISTRY,301(1-2),173-179.
MLA Ho, Y. W.,et al."Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast".MOLECULAR AND CELLULAR BIOCHEMISTRY 301.1-2(2007):173-179.
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