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学科主题: 药学
题名:
Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng
作者: Chan, RYK1; Chen, WF1; Dong, A1; Guo, D1; Wong, MS1
刊名: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
发表日期: 2002-08-01
卷: 87, 期:8, 页:3691-3695
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: DIETARY PHYTOESTROGENS ; RECEPTOR ; CELLS ; DIFFERENTIATION ; PHARMACOLOGY ; MODULATION ; SAPONINS ; LIGAND ; BETA ; MICE
英文摘要:

Ginsenosides have demonstrated pharmacological effects in the central nervous, cardiovascular, and endocrine systems. We hypothesize that ginsenosides might mediate some of their actions by binding to the estrogen receptor, as they share many of the protective actions of estrogen in various physiological systems. The present study is aimed to determine whether ginsenoside Rg1 can act like an estrogen analog in stimulating human breast cancer cell growth as well as in the activation of estrogen response element-luciferase activity in HeLa cell. Rg1, but not its aglycone, stimulates [methyl-(3)H] thymidine incorporation in estrogen receptor-positive MCF-7 in a dose-dependent manner (10(-15)-10(-7) W. The stimulation of MCF-7 cell proliferation by 3 x 10(-13) m Rg1 can be blocked by 10(-6) m of the estrogen antagonist ICI 182780. Moreover, Rg1 stimulates estrogen response element-luciferase reporter gene activity in HeLa cells with an optimal dose of 3 x 10(-10) m. Such stimulation can also be blocked by 10(-6) m ICI 182780. In addition, Rg1 has no effect on [methyl-(3)H]thymidine incorporation in estrogen receptor-negative human breast cancer cells (MDA-MB-231). Furthermore, Rg1 failed to displace the specific binding of [3 111 17beta-estradiol to MCF-7 cell lysates, suggesting that no direct interaction of Rg1 with estrogen receptor is needed for its estrogenic action. Our results indicate that ginsenosides Rg1 has estrogen-like activity and should be classified as a novel class of potent phytoestrogen.

语种: 英语
WOS记录号: WOS:000177285400028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51489
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Hong Kong Polytech Univ, Open Lab Chirotechnol, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Chan, RYK,Chen, WF,Dong, A,et al. Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2002,87(8):3691-3695.
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