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学科主题临床医学
Anti-glomerular basement membrane antibody disease is an uncommon cause of end-stage renal disease
Tang, Wen1,2,3; McDonald, Stephen P.1,4,5; Hawley, Carmel M.1,3; Badve, Sunil V.1,3; Boudville, Neil C.1,6; Brown, Fiona G.1,7; Clayton, Philip A.1,8; Campbell, Scott B.1,3; de Zoysa, Janak R.1,9; Johnson, David W.1,3
关键词Anti-gbm Disease Anti-glomerular Basement Membrane Antibody Disease End-stage Renal Disease Kidney Failure Renal Function Recovery Renal Transplantation
刊名KIDNEY INTERNATIONAL
2013-03-01
DOI10.1038/ki.2012.375
83期:3页:503-510
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GBM DISEASE ; GOODPASTURES-SYNDROME ; TRANSPLANTATION ; GLOMERULONEPHRITIS ; CHINESE ; RECURRENCE ; VASCULITIS ; PROGNOSIS ; OUTCOMES ; THERAPY
英文摘要

There are few reports regarding outcomes of anti-glomerular basement membrane (GBM) disease in patients who underwent renal replacement therapy. To help define this we studied all patients with anti-GBM disease who started renal replacement therapy for end-stage renal disease (ESRD) in Australia and New Zealand (ANZDATA Registry) between 1963 and 2010 encompassing 449 individuals (0.8 percent of all ESRD patients). The median survival on dialysis was 5.93 years with death predicted by older age and a history of pulmonary hemorrhage. Thirteen patients recovered renal function, although 10 subsequently experienced renal death after a median period of 1.05 years. Of the 224 patients who received their first renal allograft, the 10-year median patient and renal allograft survival rates were 86% and 63%, respectively. Six patients experienced anti-GBM disease recurrence in their allograft, which led to graft failure in two. Using multivariable Cox regression analysis, patients with anti-GBM disease had comparable survival on dialysis or following renal transplantation (hazard ratios of 0.86 and 1.03, respectively) compared to those with ESRD due to other causes. Also, renal allograft survival (hazard ratio of 1.03) was not altered compared to other diseases requiring a renal transplant. Thus, anti-GBM disease was an uncommon cause of ESRD, and not associated with altered risks of dialysis, transplant or first renal allograft survival. Death on dialysis was predicted by older age and a history of pulmonary hemorrhage. Kidney International (2013) 83, 503-510; doi:10.1038/ki.2012.375; published online 19 December 2012

语种英语
WOS记录号WOS:000316156100023
项目编号30900681 ; D09050704310905 ; 76496-02
资助机构Baxter Healthcare Pty ; Fresenius Medical Care ; Queensland Government Health Research Fellowship ; Amgen ; Roche ; AMGEN Australia ; Genzyme Australia ; Jansen-Cilag ; Shire ; Abbott ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Fund of Peking University Third Hospital
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51491
专题北京大学第三临床医学院_肾内科
作者单位1.ANZDATA Registry, Adelaide, SA, Australia
2.Peking Univ, Hosp 3, Div Nephrol, Beijing 100871, Peoples R China
3.Univ Queensland, Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia
4.Univ Adelaide, Cent Northern Adelaide Renal Serv, Dept Nephrol & Transplantat Serv, Adelaide, SA, Australia
5.Univ Adelaide, Transplantat Serv, Dept Nephrol & Transplantat Serv, Adelaide, SA, Australia
6.Univ Western Australia, Sir Charles Gairdner Hosp Unit, Sch Med & Pharmacol, Perth, WA 6009, Australia
7.Monash Med Ctr, Dept Nephrol, Melbourne, Vic, Australia
8.Royal Prince Alfred Hosp, Dept Renal Med, Sydney, NSW, Australia
9.North Shore Hosp, Dept Renal Med, Auckland, New Zealand
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Tang, Wen,McDonald, Stephen P.,Hawley, Carmel M.,et al. Anti-glomerular basement membrane antibody disease is an uncommon cause of end-stage renal disease[J]. KIDNEY INTERNATIONAL,2013,83(3):503-510.
APA Tang, Wen.,McDonald, Stephen P..,Hawley, Carmel M..,Badve, Sunil V..,Boudville, Neil C..,...&Johnson, David W..(2013).Anti-glomerular basement membrane antibody disease is an uncommon cause of end-stage renal disease.KIDNEY INTERNATIONAL,83(3),503-510.
MLA Tang, Wen,et al."Anti-glomerular basement membrane antibody disease is an uncommon cause of end-stage renal disease".KIDNEY INTERNATIONAL 83.3(2013):503-510.
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