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学科主题: 药学
题名:
High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients
作者: Wang, Zheng1,2; Wen, Lijun1,2; Ma, Xiao1,2; Chen, Zijun3; Yu, Yunhui1,2; Zhu, Jian1,2; Wang, Yanping1,2; Liu, Zhenming4; Liu, Haiyan1,2; Wu, Depei1,2; Zhou, Dapeng5; Li, Yunsen1,2
关键词: acute myeloid leukemia ; glycosphingolipidomics ; lactotriaosylceramide ; Lc3 synthase ; mass spectrometry
刊名: GLYCOBIOLOGY
发表日期: 2012-07-01
DOI: 10.1093/glycob/cws061
卷: 22, 期:7, 页:930-938
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: TRAP MASS-SPECTROMETRY ; RETINOIC ACID ; UDP-GLCNAC ; CELLS ; GLYCOLIPIDS ; SERIES ; LACTOSYLCERAMIDE ; BIOSYNTHESIS ; GANGLIOSIDES ; SEQUENCE
英文摘要:

Glycosphingolipids (GSLs) are information-bearing biomolecules that play critical roles in embryonic development, signal transduction and carcinogenesis. Previous studies indicate that certain GSLs are associated with differentiation in acute myeloid leukemia (AML) cells. In this study, we collected bone marrow samples from healthy donors and AML patients and analyzed the GSL expression profiles comprehensively using electrospray ionization linear ion-trap mass spectrometry. The results showed that AML patients had higher expression of the GSL lactotriaosylceramide (Lc3), GM3 and neolactotetraosylceramide (nLc4) in their bone marrow than did the healthy donors (P < 0.05), especially the M1 subtype of AML. To further explore the molecular mechanisms of Lc3, we examined the expression of the Lc3 synthase beta 1,3-N-acetylglucosaminyltransferase5 (beta 3Gn-T5) and found that the bone marrow samples of AML patients had 16-fold higher expression of beta 3Gn-T5 than those of healthy donors (P < 0.05). Our results suggest that AML-associated GSLs Lc3, GM3 and nLc4 are possibly involved in initiation and differentiation of AML.

语种: 英语
所属项目编号: 31000370 ; BK2011288 ; IRT1075 ; SWG0904 ; CA16672 ; AI079232 ; AI078898 ; P30-AI36211
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Program for Changjiang Scholars and Innovative Research Team in University ; Suzhou Key Laboratories ; National Institutes of Health through MD Anderson&prime ; s Cancer Center
WOS记录号: WOS:000304195500005
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51497
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Soochow Univ, Lab Cellular & Mol Tumor Immunol, Affiliated Hosp 1, Inst Biol Sci, Suzhou 215123, Peoples R China
2.Soochow Univ, Lab Cellular & Mol Tumor Immunol, Affiliated Hosp 1, Inst Med Sci, Suzhou 215123, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Coll Chinese Mat Med, Shanghai, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
5.Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA

Recommended Citation:
Wang, Zheng,Wen, Lijun,Ma, Xiao,et al. High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients[J]. GLYCOBIOLOGY,2012,22(7):930-938.
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