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学科主题: 临床医学
题名:
Relationship of CD44(+)CD24(-/low) breast cancer stem cells and axillary lymph node metastasis
作者: Wei, Wei1; Hu, Hui1; Tan, Haosheng1; Chow, Louis W. C.2; Yip, Adrian Y. S.2; Loo, Wings T. Y.2
刊名: JOURNAL OF TRANSLATIONAL MEDICINE
发表日期: 2012-09-19
DOI: 10.1186/1479-5876-10-S1-S6
卷: suppl.1
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: MT-100-TC MAMMARY-CARCINOMA ; RATS BEARING ; CD44(+)/CD24(-) ; THERAPY ; MARKERS ; TUMORS
英文摘要:

Background: Axillary node staging plays an important role in the prognostic evaluation and planning of adjuvant treatment. Breast cancer stem cells, identified on the basis of CD44(+)CD24(-/low) expression, are associated with metastases and drug resistance. It is therefore important to investigate the proportion of CD44(+)CD24(-/low) breast cancer stem cells for the diagnosis of metastases in axillary nodes.

Methods: Thirty-two ipsilateral axillary lymph nodes were collected from patients diagnosed with invasive breast cancer. Each lymph node (LN) was divided into two equals - one was examined by H&E staining, while the other was made into a single cell suspension to study the content of CD44(+)CD24(-/low) cells by flow cytometry (FCM). The relationship was investigated between the content of CD44(+)CD24(-/low) cells and metastases in axillary nodes which were confirmed by histology. Associations were tested using the chi-square test (linear-by-linear association), and the significance level was set at a value of p < 0.05.

Results: In the 32 axillary nodes, the level of CD44(+)CD24(-/low) cells was determined to be between 0 and 18.4%: there was no presence of CD44+CD24-/low cells in 9 LNs, of which 2 had confirmed metastasis; there were less than 10% CD44+CD24-/low cells in 12 LNs, of which 6 had confirmed metastasis; and there were more than 10% CD44+CD24-/low cells in 11 LNs, of which 9 had confirmed metastasis. A higher percentage of detected CD44(+)CD24(-/low) cells was significantly associated with more confirmed LN metastases (p = 0.009).

Conclusions: CD44(+)CD24(-/low) breast cancer stem cells might help clinicians to determine the presence of LN metastases. However, its prognostic value remains unclear, while histological diagnosis is still the gold standard.

语种: 英语
WOS记录号: WOS:000309359300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51500
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Breast Surg, Shenzhen, Guangdong, Peoples R China
2.Organisat Oncol & Translat Res & UNIMED Med Inst, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wei, Wei,Hu, Hui,Tan, Haosheng,et al. Relationship of CD44(+)CD24(-/low) breast cancer stem cells and axillary lymph node metastasis[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2012,suppl.1.
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