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Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats
Wang Huai-qing1,3; Zou Jun-jie2; Zhou Xiang-hai1; Ji Li-nong1; Liu Zhi-min2
关键词Tongxinluo Streptozotocin Diabetes Oxidative Stress Antioxidants Beta-cell Function
刊名CHINESE MEDICAL JOURNAL
2012-10-20
DOI10.3760/cma.j.issn.0366-6999.2012.20.014
125期:20页:3675-3680
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; OXIDATIVE STRESS ; CARDIOVASCULAR-DISEASE ; REACTIVE OXYGEN ; MELATONIN ; MECHANISM ; INJURY ; OXIDE ; COMPLICATIONS ; INTERVENTION
英文摘要

Background Oxidative stress has been implicated in the onset and progression of diabetes. Tongxinluo is a traditional Chinese medicine with potent antioxidant properties. The aim of this study was to test the hypothesis that pretreatment with Tongxinluo has similar effects as melatonin on preventing hyperglycemia and beta-cell damage in a rat model of streptozotocin (STZ)-induced diabetes.

Methods Forty male Sprague Dawley rats were randomly assigned to four groups (n=10 each): normal control (NC) group; STZ group (70 mg/kg, i.p.); Tongxinluo (1.0 g.kg(-1).d(-1)) pretreated (TXL+STZ) group and melatonin (200 mu g.kg(-1).d(-1)) pretreated (MLT+STZ) group. Tongxinluo and melatonin were administered by gavage beginning 8 days before STZ injection and continuing until the end of the study (15 days after STZ administration). Blood glucose levels and body weights, malondialdehyde (MDA), and reduced glutathione (GSH) levels were measured, and immunofluorescence studies were performed in all of the groups.

Results Pretreatment with Tongxinluo, as with melatonin, attenuated severe hyperglycemia and weight loss induced by STZ. In pancreatic homogenates, MDA levels were significantly lower and GSH levels were significantly higher in Tongxinluo pretreated group and in melatonin pretreated group than those in STZ group. Values of insulin staining were significantly improved in Tongxinluo pretreated group and in melatonin pretreated group as compared with those in STZ group.

Conclusions Tongxinluo, as melatonin, prevented hyperglycemia and beta-cell destruction induced by STZ in rats through reducing oxidative stress in pancreatic tissues. Tongxinluo may provide an alternative therapy for the prevention and treatment of diabetes. Chin Med J 2012;125(20):3675-3680

语种英语
WOS记录号WOS:000311265100014
项目编号2005 CB 523304
资助机构National Basic Research Program (973 Program) in China (Ministry of Science and Technology)
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51501
专题北京大学第二临床医学院
作者单位1.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Ctr Diabet, Beijing 100044, Peoples R China
2.Secondary Mil Med Univ, Dept Endocrinol & Metab, Changzheng Hosp, Shanghai 200003, Peoples R China
3.China Three Gorges Univ, Dept Endocrinol & Metab, Peoples Hosp Yichang 1, Yichang 443000, Hubei, Peoples R China
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Wang Huai-qing,Zou Jun-jie,Zhou Xiang-hai,et al. Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats[J]. CHINESE MEDICAL JOURNAL,2012,125(20):3675-3680.
APA Wang Huai-qing,Zou Jun-jie,Zhou Xiang-hai,Ji Li-nong,&Liu Zhi-min.(2012).Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats.CHINESE MEDICAL JOURNAL,125(20),3675-3680.
MLA Wang Huai-qing,et al."Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats".CHINESE MEDICAL JOURNAL 125.20(2012):3675-3680.
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