|Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism|
|Wang, Xin1; Axelsson, Jonas1; Nordfors, Louise1; Qureshi, A. Rashid1; Avesani, Carla1; Barany, Peter1; Schalling, Martin1; Heimburger, Olof1; Lindholm, Bengt1; Stenvinkel, Peter1|
|关键词||Body Composition Dialysis Fat Mass Polymorphism Ucp2|
|刊名||NEPHROLOGY DIALYSIS TRANSPLANTATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Transplantation ; Urology & Nephrology|
|研究领域[WOS]||Transplantation ; Urology & Nephrology|
|关键词[WOS]||PERITONEAL-DIALYSIS ; ADIPOSE-TISSUE ; MESSENGER-RNA ; BODY-MASS ; HEMODIALYSIS-PATIENTS ; ENERGY-METABOLISM ; INFLAMMATION ; OBESITY ; EXPRESSION ; SURVIVAL|
Background. A high body mass index (BMI) has been reported to confer a survival advantage in end-stage renal disease (ESRD) patients. On the other hand, body fat accumulation, especially visceral adipose tissue, is an important risk factor for cardiovascular disease, as well as a clinically important source of adipokines. Uncoupling protein 2 (UCP2) uncouples respiration from ATP synthesis, thus regulating energy expenditure and fat oxidation. In this longitudinal cohort study, we investigated the impact of the UCP2 insertion/deletion (ins/del) polymorphism on body composition changes in ESRD patients starting dialysis.
Methods. A total of 222 incident Caucasian ESRD patients (mean age 53 +/- 12 years; 60% males) were investigated close to the start of dialysis with peritoneal dialysis (PD; n = 126) or haemodialysis (HD; n = 96), and again after about 1 year (n = 159). Genotyping of the UCP2 ins/del polymorphism was performed in the patients and in 207 healthy controls. Dual-energy X-ray absorptiometry was conducted at baseline and after 1 year to monitor body composition.
Results. While HD patients and PD patients with the ins/del genotype did not display any changes in body composition, the 48 PD patients with the del/del genotype that completed follow-up had a significant increase; Delta BMI (0.7 +/- 1.8 kg/m(2)), Delta body fat mass (3.5 +/- 3.8 kg) and Delta truncal fat mass (1.7 +/- 1.2 kg). In a multiple linear regression analysis, the del/del genotype was an independent predictor of the increase in truncal fat mass in PD patients (F-ratio = 7.99, P < 0.05) together with age and diabetes mellitus.
Conclusions. PD patients, but not HD patients, with the UCP2 del/del genotype showed a significant increase in total and truncal fat mass during the first year of dialysis therapy, suggesting a possible role for UCP2 in dissipating the excess energy of a high-glucose environment.
|作者单位||1.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, S-10401 Stockholm, Sweden|
2.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, S-10401 Stockholm, Sweden
3.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100871, Peoples R China
4.Karolinska Inst, Dept Mol Med & Surg, S-10401 Stockholm, Sweden
|Wang, Xin,Axelsson, Jonas,Nordfors, Louise,et al. Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2007,22(1):196-202.|
|APA||Wang, Xin.,Axelsson, Jonas.,Nordfors, Louise.,Qureshi, A. Rashid.,Avesani, Carla.,...&Stenvinkel, Peter.(2007).Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism.NEPHROLOGY DIALYSIS TRANSPLANTATION,22(1),196-202.|
|MLA||Wang, Xin,et al."Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism".NEPHROLOGY DIALYSIS TRANSPLANTATION 22.1(2007):196-202.|