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Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells
Jang, Moon Hee1; Piao, Xiang Lan1; Kim, Hyun Young1; Cho, Eun Jung1; Baek, Seung Hoon1; Kwon, Sung Won1; Park, Jeong Hill1
关键词Beta-amyloid Alzheimer&Prime s Disease Vitisin a Heyneanol a Resveratrol Oligomer Vitis Amurensis Reactive Oxygen Species
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2007-06-01
30期:6页:1130-1134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ALZHEIMERS-DISEASE ; TRANS-RESVERATROL ; HEYNEANOL-A ; IN-VIVO ; PEPTIDE ; NEUROTOXICITY ; MODEL ; APOPTOSIS ; ROOTS ; OLIGOSTILBENES
英文摘要

Oxidative damage induced by beta-amyloid (A beta) is closely associated with the hallmark pathologies of Alzheimer′s disease (AD) and may play a critical role in the development of AD. In this study, the protective effects of vitisin A and heyneanol A, resveratrol oligomers isolated from Vitis amurensis RuPR. (Vitaceae), against A beta-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure of PC12 cells to the A beta (20 mu M) for 24 h resulted in neuronal cell death, whereas pretreatment with vitisin A or heyneanol A at the concentration range of 5-50 mu M reduced A beta-induced cell death. In addition, A beta-induced elevation of reactive oxygen species generation, the primary cause of A beta-induced oxidative stress, was attenuated by treatment of vitisin A or heyneanol A (10, 25, 50 mu M). A beta-treated cells also displayed characteristic features of apoptosis such as induction of DNA fragmentation and caspase-3 activation, but vitisin A and heyneanol A (10, 50 mu M) significantly suppressed these events. These results suggest that vitisin A and heyneanol A prevent A beta-induced neurotoxicity through attenuating oxidative stress induced by A beta and may be useful as potential preventive or therapeutic agents for AD.

语种英语
WOS记录号WOS:000247495000018
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51508
专题北京大学药学院
作者单位1.Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jang, Moon Hee,Piao, Xiang Lan,Kim, Hyun Young,et al. Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2007,30(6):1130-1134.
APA Jang, Moon Hee.,Piao, Xiang Lan.,Kim, Hyun Young.,Cho, Eun Jung.,Baek, Seung Hoon.,...&Park, Jeong Hill.(2007).Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,30(6),1130-1134.
MLA Jang, Moon Hee,et al."Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 30.6(2007):1130-1134.
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