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学科主题: 药学
题名:
Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells
作者: Jang, Moon Hee1; Piao, Xiang Lan1; Kim, Hyun Young1; Cho, Eun Jung1; Baek, Seung Hoon1; Kwon, Sung Won1; Park, Jeong Hill1
关键词: beta-amyloid ; Alzheimer&prime ; s disease ; vitisin A ; heyneanol A ; resveratrol oligomer ; Vitis amurensis ; reactive oxygen species
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2007-06-01
卷: 30, 期:6, 页:1130-1134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ALZHEIMERS-DISEASE ; TRANS-RESVERATROL ; HEYNEANOL-A ; IN-VIVO ; PEPTIDE ; NEUROTOXICITY ; MODEL ; APOPTOSIS ; ROOTS ; OLIGOSTILBENES
英文摘要:

Oxidative damage induced by beta-amyloid (A beta) is closely associated with the hallmark pathologies of Alzheimer′s disease (AD) and may play a critical role in the development of AD. In this study, the protective effects of vitisin A and heyneanol A, resveratrol oligomers isolated from Vitis amurensis RuPR. (Vitaceae), against A beta-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure of PC12 cells to the A beta (20 mu M) for 24 h resulted in neuronal cell death, whereas pretreatment with vitisin A or heyneanol A at the concentration range of 5-50 mu M reduced A beta-induced cell death. In addition, A beta-induced elevation of reactive oxygen species generation, the primary cause of A beta-induced oxidative stress, was attenuated by treatment of vitisin A or heyneanol A (10, 25, 50 mu M). A beta-treated cells also displayed characteristic features of apoptosis such as induction of DNA fragmentation and caspase-3 activation, but vitisin A and heyneanol A (10, 50 mu M) significantly suppressed these events. These results suggest that vitisin A and heyneanol A prevent A beta-induced neurotoxicity through attenuating oxidative stress induced by A beta and may be useful as potential preventive or therapeutic agents for AD.

语种: 英语
WOS记录号: WOS:000247495000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51508
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Jang, Moon Hee,Piao, Xiang Lan,Kim, Hyun Young,et al. Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2007,30(6):1130-1134.
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