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学科主题口腔医学
Inorganic-Organic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoprotein
Dai, Lin2; Qi, Yi-Pin1; Niu, Li-Na3; Liu, Yan4; Pucci, Cesar R.5; Looney, Stephen W.6; Ling, Jun-Qi1; Pashley, David H.7; Tay, Franklin R.8
刊名CRYSTAL GROWTH & DESIGN
2011-08-01
DOI10.1021/cg200663v
11期:8页:3504-3511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Crystallography ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Crystallography ; Materials Science
关键词[WOS]CALCIUM-PHOSPHATE ; RECONSTITUTED COLLAGEN ; BONE-STRUCTURE ; IN-VITRO ; MINERALIZATION ; FIBRILS ; BIOMINERALIZATION ; CRYSTALLIZATION ; HYDROXYAPATITE ; PRECIPITATION
英文摘要

Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nano-precursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.

语种英语
WOS记录号WOS:000293356400025
项目编号R21 DE019213
资助机构NIDCR ; Georgia Health Sciences University
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51510
专题北京大学口腔医学院_牙周科
作者单位1.First Hosp Wuhan, Dept Stomatol, Wuhan, Peoples R China
2.Sun Yat Sen Univ, Dept Operat Dent & Endodont, Guanghua Sch Stomatol, Guangzhou 510275, Guangdong, Peoples R China
3.Fourth Mil Med Univ, Dept Prosthodont, Sch Stomatol, Xian 710032, Peoples R China
4.Peking Univ, Dept Orthodont, Sch Stomatol, Beijing 100871, Peoples R China
5.Univ Estadual Paulista, Fac Odontol Sao Jose de Campos, UNESP, Sao Paulo, Brazil
6.Georgia Hlth Sci Univ, Dept Biostat, Augusta, GA 30912 USA
7.Georgia Hlth Sci Univ, Dept Oral Biol, Augusta, GA 30912 USA
8.Georgia Hlth Sci Univ, Dept Endodont, Augusta, GA 30912 USA
推荐引用方式
GB/T 7714
Dai, Lin,Qi, Yi-Pin,Niu, Li-Na,et al. Inorganic-Organic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoprotein[J]. CRYSTAL GROWTH & DESIGN,2011,11(8):3504-3511.
APA Dai, Lin.,Qi, Yi-Pin.,Niu, Li-Na.,Liu, Yan.,Pucci, Cesar R..,...&Tay, Franklin R..(2011).Inorganic-Organic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoprotein.CRYSTAL GROWTH & DESIGN,11(8),3504-3511.
MLA Dai, Lin,et al."Inorganic-Organic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoprotein".CRYSTAL GROWTH & DESIGN 11.8(2011):3504-3511.
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