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Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis
Yan, Ying-Bin1,4; Zhang, Yi1; Gan, Ye-Hua2,3; An, Jin-Gang1; Li, Jiang-Ming1; Xiao, E.1
关键词Temporomandibular Joint Bony Ankylosis Trauma Animal Model
刊名JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
2013-09-01
DOI10.1016/j.jcms.2012.03.011
41期:6页:476-486
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]TEMPOROMANDIBULAR-JOINT ANKYLOSIS ; INTRACAPSULAR CONDYLAR FRACTURE ; MODEL ; RATS ; ETIOLOGY ; DISC
英文摘要

Objective: The purpose of this paper is to summarize our experiences in creating an animal model of TMJ bony ankylosis based on 2 sequential experiments.

Methods: Two sequential experiments were performed with the aim of creating a model of TMJ bony ankylosis. Seven growing sheep were used in the first experiment, in which 1 was served as a control animal. Condylar fracture with disc preservation was performed on the control side. On the contralateral side, condylar fracture, excision of the lateral 213 disc and injury to the glenoid fossa were performed to induce bony ankylosis. Three animals were sacrificed respectively at 3 and 6 months after surgery. In the second experiment, 7 growing sheep were used. The only difference of modeling between the 2 experiments was that more serious injury to the glenoid fossa was made in the ankylosis-induced side in experiment 2. Three, 2, and 2 animals were sacrificed respectively at 1, 3, and 6 months postoperatively. The TMJ complexes were examined by computed tomography (CT) and histological evaluation.

Results: In experiment 1, only fibrous ankylosis was observed in the ankylosis-induced side both at 3 and 6 months postoperatively. In experiment 2, CT and histological evaluation showed that the outcomes of the ankylosis-induced side were fibrous-bony ankylosis, fibrous-bony ankylosis, and bony ankylosis respectively at 1, 3, and 6 months after surgery.

Conclusion: Through summarizing the differences of the modeling and the different outcomes in the 2 experiments, we concluded that severe damage to the glenoid fossa played an important role in the development of TMJ bony ankylosis. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000324849000006
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51512
专题北京大学口腔医学院
北京大学口腔医学院_外科
北京大学口腔医学院_中心实验室
作者单位1.Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Mol Biol Lab, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Ctr Temporomandibular Disorders & Orofacial Pain, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Tianjin Stomatol Hosp, Dept Oral & Maxillofacial Surg, Tianjin 300041, Peoples R China
推荐引用方式
GB/T 7714
Yan, Ying-Bin,Zhang, Yi,Gan, Ye-Hua,et al. Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2013,41(6):476-486.
APA Yan, Ying-Bin,Zhang, Yi,Gan, Ye-Hua,An, Jin-Gang,Li, Jiang-Ming,&Xiao, E..(2013).Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis.JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,41(6),476-486.
MLA Yan, Ying-Bin,et al."Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis".JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 41.6(2013):476-486.
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