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学科主题: 药学
题名:
Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action
作者: Chen, Bi1; Liao, Wen-Qiany2; Xu, Ning3; Xu, Hao2; Wen, Jian-Yan2; Yu, Chang-An2; Liu, Xiang-Yuan3; Li, Chang-Ling1; Zhao, Shu-Min4; Campbell, William4
关键词: Adiponectin ; Cerebral ischemia/reperfusion ; Anti-inflammation ; Cytokines ; Nuclear factor-kappa B
刊名: BRAIN RESEARCH
发表日期: 2009-06-01
DOI: 10.1016/j.brainres.2009.04.002
卷: 1273, 页:129-137
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: HUMAN CEREBROSPINAL-FLUID ; BLOOD-BRAIN-BARRIER ; INFLAMMATORY RESPONSE ; NITRIC-OXIDE ; IN-VIVO ; STROKE ; RECEPTORS ; HYPOTHALAMUS ; EXPRESSION ; OBESITY
英文摘要:

Adiponectin (APN), a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardio- and cerebrovascular disorders. Hypoadiponectinemia is associated with ischemic cerebrovascular disease, however, little is known about the cerebroprotective action of APN as well as its molecular mechanisms. in the present study, the role of APN in the pathogenesis of acute cerebral injury was investigated. Rats were divided into three groups: (i) a sham operation group; (ii) an ischemia/reperfusion (I/R) group, rats were subjected to 1 h middle cerebral artery occlusion followed by 23 h reperfusion (I/R); (iii) a APN-treated group, two bolus of 5 mu g APN was administered through jugular vein before and after operation. I/R resulted in obvious cerebral infarct size, neurological deficits, and increased expression of endogenous immunoglobin G and matrix metalloprotemase 9, which can be significantly diminished by administration of APN. We also found that APN can significantly inhibited cerebral expression of myeloperoxidase, a distinct indicator of inflammatory cell infiltration, and inflammatory cytokines, interleukin (IL)-1 beta, tumor necrosis factor-alpha and IL-8 in response to I/R, suggesting that APN exerts potent anti-inflammatory actions. Furthermore, nuclear factor (NF)-kappa B (p65), a critical transcription factor involved in inflammatory reactions, was observed predominantly located in the nucleus after I/R, whereas APN can obviously inhibit its translocation from cytoplasm into the nucleus. Results of this study demonstrate that APN exerts a potent cerebroprotective function through its anti-inflammatory action, and NF-kappa B (p65) is a key component in this process. APN might be potential molecular targets for ischemic stroke therapy. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30772012
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000267516600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51524
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.PepMetr & Pegasus Pharmaceut Grp Inc, Richmond, BC V6X 1Z7, Canada
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Bi,Liao, Wen-Qiany,Xu, Ning,et al. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action[J]. BRAIN RESEARCH,2009,1273:129-137.
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