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Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action
Chen, Bi1; Liao, Wen-Qiany2; Xu, Ning3; Xu, Hao2; Wen, Jian-Yan2; Yu, Chang-An2; Liu, Xiang-Yuan3; Li, Chang-Ling1; Zhao, Shu-Min4; Campbell, William4
关键词Adiponectin Cerebral Ischemia/reperfusion Anti-inflammation Cytokines Nuclear Factor-kappa b
刊名BRAIN RESEARCH
2009-06-01
DOI10.1016/j.brainres.2009.04.002
1273页:129-137
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]HUMAN CEREBROSPINAL-FLUID ; BLOOD-BRAIN-BARRIER ; INFLAMMATORY RESPONSE ; NITRIC-OXIDE ; IN-VIVO ; STROKE ; RECEPTORS ; HYPOTHALAMUS ; EXPRESSION ; OBESITY
英文摘要

Adiponectin (APN), a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardio- and cerebrovascular disorders. Hypoadiponectinemia is associated with ischemic cerebrovascular disease, however, little is known about the cerebroprotective action of APN as well as its molecular mechanisms. in the present study, the role of APN in the pathogenesis of acute cerebral injury was investigated. Rats were divided into three groups: (i) a sham operation group; (ii) an ischemia/reperfusion (I/R) group, rats were subjected to 1 h middle cerebral artery occlusion followed by 23 h reperfusion (I/R); (iii) a APN-treated group, two bolus of 5 mu g APN was administered through jugular vein before and after operation. I/R resulted in obvious cerebral infarct size, neurological deficits, and increased expression of endogenous immunoglobin G and matrix metalloprotemase 9, which can be significantly diminished by administration of APN. We also found that APN can significantly inhibited cerebral expression of myeloperoxidase, a distinct indicator of inflammatory cell infiltration, and inflammatory cytokines, interleukin (IL)-1 beta, tumor necrosis factor-alpha and IL-8 in response to I/R, suggesting that APN exerts potent anti-inflammatory actions. Furthermore, nuclear factor (NF)-kappa B (p65), a critical transcription factor involved in inflammatory reactions, was observed predominantly located in the nucleus after I/R, whereas APN can obviously inhibit its translocation from cytoplasm into the nucleus. Results of this study demonstrate that APN exerts a potent cerebroprotective function through its anti-inflammatory action, and NF-kappa B (p65) is a key component in this process. APN might be potential molecular targets for ischemic stroke therapy. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000267516600014
项目编号30772012
资助机构National Natural Science Foundation of China
引用统计
被引频次:74[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51524
专题北京大学药学院
作者单位1.PepMetr & Pegasus Pharmaceut Grp Inc, Richmond, BC V6X 1Z7, Canada
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100871, Peoples R China
3.China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Bi,Liao, Wen-Qiany,Xu, Ning,et al. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action[J]. BRAIN RESEARCH,2009,1273:129-137.
APA Chen, Bi.,Liao, Wen-Qiany.,Xu, Ning.,Xu, Hao.,Wen, Jian-Yan.,...&Campbell, William.(2009).Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action.BRAIN RESEARCH,1273,129-137.
MLA Chen, Bi,et al."Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action".BRAIN RESEARCH 1273(2009):129-137.
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