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学科主题: 公共卫生
题名:
Job stress, gene polymorphism of beta(2)-AR, and prevalence of hypertension
作者: Yu, Shan-Fa1,2; Zhou, Wen-Hui2; Jiang, Kai-You1; Gu, Gui-Zheng2; Wang, Sheng1
关键词: job stress ; hypertension ; beta(2)-AR ; gene polymorphism
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2008-06-01
卷: 21, 期:3, 页:239-246
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: CORONARY-HEART-DISEASE ; EFFORT-REWARD IMBALANCE ; BETA(2)-ADRENERGIC RECEPTOR GENE ; PSYCHOSOCIAL WORK-ENVIRONMENT ; BLOOD-PRESSURE ; WOMEN ; RISK ; MEN ; POPULATION ; MODELS
英文摘要:

Objective To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. Methods A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta(2)-AR genotypes and allele frequencies at amino acid positions 16 (beta(2)-AR-16: Arg -> Gly) and 27 (beta(2)-AR-27: Gln -> Glu) were identified by PCR-RFLP. Results Job stress was related with the prevalence of hypertension in males (P<0.05), whereas no significant relationship was found in females (P>0.05). Differences in genotypes and allele frequencies of the beta(2)-AR-16 were statistically significant between the hypertension and control groups (P<0.05), whereas those of beta(2)-AR-27 were not (P>0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P<0.01 or 0.05). Conclusion High job stress and polymorphism of beta(2)-AR-16 have an interactive effect on the prevalence of hypertension in male workers.

语种: 英语
WOS记录号: WOS:000256720400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51525
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Henan Prov Inst Occupat Med, Zhengzhou 450052, Henan, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Yu, Shan-Fa,Zhou, Wen-Hui,Jiang, Kai-You,et al. Job stress, gene polymorphism of beta(2)-AR, and prevalence of hypertension[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2008,21(3):239-246.
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