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学科主题: 临床医学
题名:
Gastrointestinal symptoms predict peritonitis rates in CAPD patients
作者: Su, Chun-yan; Pei, Juan; Lu, Xin-hong; Tang, Wen; Wang, Tao
关键词: end stage renal disease ; continuous ambulatory peritoneal dialysis ; peritonitis ; gastrointestinal symptom
刊名: CLINICAL NEPHROLOGY
发表日期: 2012-04-01
DOI: 10.5414/CN107249
卷: 77, 期:4, 页:267-274
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: DIALYSIS-RELATED PERITONITIS ; CHRONIC-RENAL-FAILURE ; ENTEROBACTERIACEAE PERITONITIS ; INFECTIONS RECOMMENDATIONS ; RISK-FACTOR ; EXIT SITE ; IMPACT ; CONSTIPATION ; POPULATIONS ; PREVALENCE
英文摘要:

Objective: Peritonitis is still one of the major causes of peritoneal dialysis (PD) patients′ dropout. In the present study, we analyzed the relationship between gastrointestinal (GI) problems and peritonitis in our CAPD patients. Methods: It is a prospective observational study. In December, 2008, 158 patients on continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months from our PD unit were included in this study. A questionnaire was used to evaluate their GI symptoms score (GISS). All patients were followed up for 24 months or until they dropped out from our PD program. All peritonitis events were recorded. Results: The patients′ PD duration was 22 (4 132) months before the study. During the 24 months follow-up, 37 patients dropped out. And 37 patients had 46 episodes of peritonitis (peritonitis group) whereas the other 121 patients did not have peritonitis (peritonitis-free group). The overall peritonitis rate was one episode per 75.87 patient months. The peritonitis free group had lower GISS (1.35 +/- 1.94 vs. 2.95 +/- 3.19, p = 0.006), higher albumin level and longer dialysis duration at baseline as compared to the peritonitis group. Multivariate Cox-regression analysis showed that only GISS (OR 1.206, 95% CI 1.093 - 1.330) and dialysis duration (OR 1.018, 95% CI 1.006 - 1.031) were the risk factors for the time to first peritonitis episodes during the follow-up. Further analysis identified 2 GISS components, belching and constipation, as the strongest predictors of peritonitis during the follow-up period (p < 0.005). Conclusion: Our study showed that GI symptoms could predict peritonitis in CAPD patients. Prevention and treatment for GI problems may thus be helpful to decrease peritonitis rate.

语种: 英语
所属项目编号: 30900681 ; D09050704310905 ; YZZ 08-5-28 ; 76496-02
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission ; Peking University Third Hospital
WOS记录号: WOS:000302828100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51531
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Div Nephrol, Beijing 100191, Peoples R China

Recommended Citation:
Su, Chun-yan,Pei, Juan,Lu, Xin-hong,et al. Gastrointestinal symptoms predict peritonitis rates in CAPD patients[J]. CLINICAL NEPHROLOGY,2012,77(4):267-274.
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