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Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy
Wang, Lin1; Zhai, Zhi-Wei2; Ji, Deng-Bo1; Li, Zhong-Wu3; Gu, Jin1
关键词Rectal Cancer Neoadjuvant Radiotherapy Cd45ro Tumor-infiltrating Lymphocytes
刊名INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
2015-06-01
DOI10.1007/s00384-015-2226-6
30期:6页:753-760
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]TOTAL MESORECTAL EXCISION ; TERM PREOPERATIVE RADIOTHERAPY ; MEMORY T-CELLS ; COLORECTAL-CANCER ; RANDOMIZED-TRIAL ; POSTOPERATIVE CHEMORADIOTHERAPY ; CLINICAL IMPACT ; DELAYED SURGERY ; TME TRIAL ; SURVIVAL
英文摘要

This study aims to evaluate the prognostic value of CD45RO(+) tumor-infiltrating lymphocytes (TILs) in locally advanced rectal cancer treated with 30 Gy/10 fraction (10f) neoadjuvant radiotherapy.

This retrospective study involved 185 patients with locally advanced rectal cancer who underwent 30 Gy/10f nRT (biologic equivalent dose, 30 Gy) followed by total mesorectal excision (TME) between August 2003 and October 2009. The density of CD45RO(+) TILs was assessed by immunohistochemistry using an image-analysis system and tissue microarray and was evaluated for its association with histopathologic features along with disease-free survival (DFS).

Following neoadjuvant radiotherapy, the median density of CD45RO(+) TILs is 654/mm(2). High density of CD45RO(+) TILs was significantly associated with increased T and N downstaging effect (p = 0.006; p = 0.014), lesser-advanced T stage (p = 0.003) and TNM stage (p = 0.022). Prolonged DFS (89.0 vs. 68.1 %) was also observed in CD45RO(+Hi) cases. On multivariate regression model, CD45RO(+) TILs (p = 0.026; odds ratio (OR), 0.436 (95 % confidence interval (CI), 0.209-0.907)), tumor differentiation (p = 0.057; OR, 1.878 (95 % CI, 0.982-3.593)), ypT stage (p = 0.066; OR, 2.383 (95 % CI, 0.943-6.025)), and ypN stage (p = 0.009; OR, 2.612 (95 % CI, 1.266-5.388)) were independent factors for DFS.

The density of CD45RO(+) TILs cannot only predict tumor downstaging and ypTNM stage for rectal cancer following 30 Gy/10f nRT but also promisingly predict long-term outcomes. These findings may be used to stratify patients and make alternative strategy of adjuvant treatment.

语种英语
WOS记录号WOS:000354708800003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51533
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_病理科
作者单位1.Chaoyang Hosp, Dept Gastrointestinal Surg, Beijing, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Colorectal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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Wang, Lin,Zhai, Zhi-Wei,Ji, Deng-Bo,et al. Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2015,30(6):753-760.
APA Wang, Lin,Zhai, Zhi-Wei,Ji, Deng-Bo,Li, Zhong-Wu,&Gu, Jin.(2015).Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy.INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,30(6),753-760.
MLA Wang, Lin,et al."Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy".INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 30.6(2015):753-760.
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