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学科主题: 公共卫生
题名:
Combined developmental toxicity of bisphenol A and genistein in micromass cultures of rat embryonic limb bud and midbrain cells
作者: Xiao, Yang1; Liu, Ran1; Xing, Lina1; Xu, Yajun2; Shang, Lanqin1; Hao, Weidong1
关键词: Bisphenol A ; Genistein ; Micromass ; Developmental toxicity ; Combined effect
刊名: TOXICOLOGY IN VITRO
发表日期: 2011-02-01
DOI: 10.1016/j.tiv.2010.10.010
卷: 25, 期:1, 页:153-159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: EXPERT PANEL REPORT ; PHYTOESTROGEN GENISTEIN ; POSTMENOPAUSAL WOMEN ; AMNIOTIC-FLUID ; SOY ISOFLAVONE ; EXPOSURE ; DIFFERENTIATION ; CANCER ; CHEMICALS ; LEUKEMIA
英文摘要:

Bisphenol A (BPA), widely used in industry and dentistry, and genistein (GEN), the predominant component of soy product, are both known environmental estrogen. In the present study, we investigated the developmental toxicity of BPA and GEN and their combined effect using micromass test, which is one of three standard alternative developmental toxicity tests recommended by European Center for the Validation of Alternative Methods (ECVAM). The results showed that IC50-P (cell proliferation) and IC50-D (cell differentiation) of BPA and GEN were approximately 20 and 5 mu g/ml, respectively. No observed adverse effect level (NOAEL) of BPA and GEN were 10 and 0.94 mu g/ml, respectively. The manifestation of BPA as a teratogen was insufficient, although the "low dose" effect should be paid attention to. While the evidence of GEN as a teratogen was solid, especially with the consideration of "high dose" application in clinical treatment. The combined effect of BPA and GEN was generally additive action except that in MB proliferation. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30771821 ; 30972501 ; 2006BKA02A02 ; 2009ZX09301-010
项目资助者: National Natural Sciences Foundations of the People&prime ; s Republic of China ; Key Projects in the National Science and Technology Pillar Program in the Eleventh Five-year Plan Period ; National Science and Technology Major Specific Project
WOS记录号: WOS:000287010600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51537
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Toxicol, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Xiao, Yang,Liu, Ran,Xing, Lina,et al. Combined developmental toxicity of bisphenol A and genistein in micromass cultures of rat embryonic limb bud and midbrain cells[J]. TOXICOLOGY IN VITRO,2011,25(1):153-159.
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