IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length
Tian, XX1; Pang, JS1; Zheng, J1; Chen, J1; To, SST1; Ng, HK1
关键词glioblastoma epidermal growth factor receptor antisense telomerase
刊名BRITISH JOURNAL OF CANCER
2002-04-22
DOI10.1038/sj/bjc/6600244
86期:8页:1328-1332
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]REVERSE-TRANSCRIPTASE HTERT ; CANCER-CELLS ; EGF-RECEPTOR ; PROLIFERATION ; EXPRESSION ; INHIBITION ; PROTEIN ; TUMORS ; PHOSPHORYLATION ; ACTIVATION
英文摘要

Epidermal growth factor receptor is overexpressed and/or amplified in up to 50% of glioblastomas, suggesting an important role of this gene in glial tumorigenesis and progression. In the present study we demonstrated that epidermal growth factor receptor is involved in regulation of telomerase activity in glioblastoma. Antisense-epidermal growth factor receptor approach was used to inhibit epidermal growth factor receptor expression of glioblastoma U87MG cells. Telomerase activity in antisense-epidermal growth factor receptor cells decreased by up to 54 folds compared with control cells. Moreover. the telomere lengths of antisense-epidermal growth factor receptor cells were shortened. In addition, the tumorigenicity of antisense-epidermal growth factor receptor cells was significantly inhibited. Taken together, there were strong correlations between tumorgenicity and epidermal growth factor receptor expression levels, and between tumongenicity and telomerase activity, These results provide evidence that epidermal growth factor receptor plays an important role in the regulation of telomerase activity of glioma cells. Our findings provide new insights into both the biological functions of epidermal growth factor receptor and the regulation of telomerase activity. The inhibition of telomerase activity triggered by anti sense-epidermal growth factor receptor treatment may reflect yet another, mechanism of antisense-epidermal growth factor receptor approach in tumour suppression, (C) 2002 Cancer Research UK.

语种英语
WOS记录号WOS:000175800700022
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51544
专题北京大学基础医学院_病理学系
作者单位1.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China
4.Hong Kong Polytech Univ, Dept Nursing & Hlth Sci, Hong Kong, Hong Kong, Peoples R China
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Tian, XX,Pang, JS,Zheng, J,et al. Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length[J]. BRITISH JOURNAL OF CANCER,2002,86(8):1328-1332.
APA Tian, XX,Pang, JS,Zheng, J,Chen, J,To, SST,&Ng, HK.(2002).Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length.BRITISH JOURNAL OF CANCER,86(8),1328-1332.
MLA Tian, XX,et al."Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length".BRITISH JOURNAL OF CANCER 86.8(2002):1328-1332.
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