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学科主题: 基础医学
题名:
Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length
作者: Tian, XX1; Pang, JS1; Zheng, J1; Chen, J1; To, SST1; Ng, HK1
关键词: glioblastoma ; epidermal growth factor receptor ; antisense ; telomerase
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2002-04-22
DOI: 10.1038/sj/bjc/6600244
卷: 86, 期:8, 页:1328-1332
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: REVERSE-TRANSCRIPTASE HTERT ; CANCER-CELLS ; EGF-RECEPTOR ; PROLIFERATION ; EXPRESSION ; INHIBITION ; PROTEIN ; TUMORS ; PHOSPHORYLATION ; ACTIVATION
英文摘要:

Epidermal growth factor receptor is overexpressed and/or amplified in up to 50% of glioblastomas, suggesting an important role of this gene in glial tumorigenesis and progression. In the present study we demonstrated that epidermal growth factor receptor is involved in regulation of telomerase activity in glioblastoma. Antisense-epidermal growth factor receptor approach was used to inhibit epidermal growth factor receptor expression of glioblastoma U87MG cells. Telomerase activity in antisense-epidermal growth factor receptor cells decreased by up to 54 folds compared with control cells. Moreover. the telomere lengths of antisense-epidermal growth factor receptor cells were shortened. In addition, the tumorigenicity of antisense-epidermal growth factor receptor cells was significantly inhibited. Taken together, there were strong correlations between tumorgenicity and epidermal growth factor receptor expression levels, and between tumongenicity and telomerase activity, These results provide evidence that epidermal growth factor receptor plays an important role in the regulation of telomerase activity of glioma cells. Our findings provide new insights into both the biological functions of epidermal growth factor receptor and the regulation of telomerase activity. The inhibition of telomerase activity triggered by anti sense-epidermal growth factor receptor treatment may reflect yet another, mechanism of antisense-epidermal growth factor receptor approach in tumour suppression, (C) 2002 Cancer Research UK.

语种: 英语
WOS记录号: WOS:000175800700022
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51544
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China
4.Hong Kong Polytech Univ, Dept Nursing & Hlth Sci, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Tian, XX,Pang, JS,Zheng, J,et al. Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length[J]. BRITISH JOURNAL OF CANCER,2002,86(8):1328-1332.
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