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学科主题: 临床医学
题名:
Effect of Glaucoma Tube Shunt Parameters on Cornea Endothelial Cells in Patients With Ahmed Valve Implants
作者: Koo, Euna B.1; Hou, Jing1,2; Han, Ying1; Keenan, Jeremy D.1,3; Stamper, Robert L.1; Jeng, Bennie H.4
关键词: glaucoma tube shunts ; endothelial cell densities ; anterior segment OCT ; specular microscopy
刊名: CORNEA
发表日期: 2015
卷: 34, 期:1, 页:37-41
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: AQUEOUS SHUNTS ; FOLLOW-UP ; MORPHOLOGY
英文摘要:

Purpose: The aim of this study was to assess the effect of various tube parameters on corneal endothelial cell density (ECD) after insertion of Ahmed valves.

Methods: Thirty-nine eyes of 33 patients with previous super-otemporal (ST) Ahmed valve implantation and 20 eyes of 13 participants with previous uncomplicated phacoemulsification and intraocular lens implantation but no history of glaucoma surgery were evaluated. Various tube parameters were measured with anterior segment optical coherence tomography. ST, central, and inferonasal (IN) ECD and pachymetry were measured. Endothelial cell loss and corneal thickness in the ST cornea was compared with those in the IN cornea.

Results: The mean age of the operated patients was 58 +/- 22 years, and the mean time since glaucoma surgery was 2.5 +/- 2.6 years. Thirty-two of the 39 study eyes were pseudophakic. The ECD was significantly lower in the ST endothelium than in the IN endothelium in eyes with glaucoma tube surgery (P < 0.001), although this relative reduction in ST ECD was not greater than that seen in pseudophakic control eyes (P = 0.16). In univariate analysis, tube angle relative to the cornea and distance from the tip of the tube to the cornea were significant risk factors for decreased ST endothelial cell loss when assessed relative to the IN ECD (P = 0.01 and P = 0.02, respectively). In multivariate analysis, only the distance of the tube tip to the cornea remained significantly associated with ST endothelial cell loss.

Conclusions: Although this was a retrospective study with inherent limitations, tubes that are closer to the cornea seem to lead to increased loss of adjacent endothelial cells.

语种: 英语
项目资助者: Research to Prevent Blindness, Inc ; That Man May See, Inc.
WOS记录号: WOS:000345924700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51545
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
3.Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA
4.Univ Maryland, Sch Med, Dept Ophthalmol & Visual Sci, Baltimore, MD 21201 USA

Recommended Citation:
Koo, Euna B.,Hou, Jing,Han, Ying,et al. Effect of Glaucoma Tube Shunt Parameters on Cornea Endothelial Cells in Patients With Ahmed Valve Implants[J]. CORNEA,2015,34(1):37-41.
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