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学科主题: 临床医学
题名:
Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis
作者: Shen, Zhanlong; Ye, Yingjiang; Bin, Liang; Yin, Mujun; Yang, Xiaodong; Jiang, Kewei; Wang, Shan
关键词: Metabolic syndrome ; Colorectal cancer ; Recurrence ; Survival ; Liver metastases ; Body mass index ; Obesity
刊名: AMERICAN JOURNAL OF SURGERY
发表日期: 2010-07-01
DOI: 10.1016/j.amjsurg.2009.05.005
卷: 200, 期:1, 页:59-63
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: MORTALITY ; ADULTS ; RISK
英文摘要:

BACKGROUND: Several studies have shown that metabolic syndrome (MS) was a risk factor for colorectal cancer, but few studies have reported the relationship between MS and the prognosis of colorectal cancer.

METHODS: Data were collected from 507 cases of colorectal carcinoma between January 2002 and March 2007 to establish the database. These patients were divided into 2 groups based on the presence of MS. We tested the prognostic value of MS in the patients. The risk of adverse events was examined by Cox proportional hazard modeling.

RESULTS: The rates of liver metastasis and tumor recurrence were higher in the group of patients with colorectal cancer accompanied by MS. Moreover, MS is one of the important elements that independently can influence the survival (colonic carcinoma: hazard ratio [HR], 1.633; 95% confidence interval [CI], 1.039-2.565; rectal carcinoma: HR, 1.939, 95% CI, 1.076-3.494) and liver metastasis (colonic carcinoma: HR, 2.619; 95% CI, 1.288-5.324; rectal carcinoma: HR, 2.814; 95% CI, .962-2.888) of both colonic and rectal carcinoma patients, and MS patients have the highest risk with worse survival and liver metastases compared with other parameters.

CONCLUSIONS: The results suggest that MS may be an important prognostic factor for colorectal cancer, decreasing the incidence of MS may improve the therapeutic efficacy of colorectal cancer. (C) 2010 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000280697900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51546
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China

Recommended Citation:
Shen, Zhanlong,Ye, Yingjiang,Bin, Liang,et al. Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis[J]. AMERICAN JOURNAL OF SURGERY,2010,200(1):59-63.
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