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学科主题临床医学
Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis
Shen, Zhanlong; Ye, Yingjiang; Bin, Liang; Yin, Mujun; Yang, Xiaodong; Jiang, Kewei; Wang, Shan
关键词Metabolic Syndrome Colorectal Cancer Recurrence Survival Liver Metastases Body Mass Index Obesity
刊名AMERICAN JOURNAL OF SURGERY
2010-07-01
DOI10.1016/j.amjsurg.2009.05.005
200期:1页:59-63
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]MORTALITY ; ADULTS ; RISK
英文摘要

BACKGROUND: Several studies have shown that metabolic syndrome (MS) was a risk factor for colorectal cancer, but few studies have reported the relationship between MS and the prognosis of colorectal cancer.

METHODS: Data were collected from 507 cases of colorectal carcinoma between January 2002 and March 2007 to establish the database. These patients were divided into 2 groups based on the presence of MS. We tested the prognostic value of MS in the patients. The risk of adverse events was examined by Cox proportional hazard modeling.

RESULTS: The rates of liver metastasis and tumor recurrence were higher in the group of patients with colorectal cancer accompanied by MS. Moreover, MS is one of the important elements that independently can influence the survival (colonic carcinoma: hazard ratio [HR], 1.633; 95% confidence interval [CI], 1.039-2.565; rectal carcinoma: HR, 1.939, 95% CI, 1.076-3.494) and liver metastasis (colonic carcinoma: HR, 2.619; 95% CI, 1.288-5.324; rectal carcinoma: HR, 2.814; 95% CI, .962-2.888) of both colonic and rectal carcinoma patients, and MS patients have the highest risk with worse survival and liver metastases compared with other parameters.

CONCLUSIONS: The results suggest that MS may be an important prognostic factor for colorectal cancer, decreasing the incidence of MS may improve the therapeutic efficacy of colorectal cancer. (C) 2010 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000280697900010
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51546
专题北京大学第二临床医学院_胃肠外科
作者单位Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Shen, Zhanlong,Ye, Yingjiang,Bin, Liang,et al. Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis[J]. AMERICAN JOURNAL OF SURGERY,2010,200(1):59-63.
APA Shen, Zhanlong.,Ye, Yingjiang.,Bin, Liang.,Yin, Mujun.,Yang, Xiaodong.,...&Wang, Shan.(2010).Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis.AMERICAN JOURNAL OF SURGERY,200(1),59-63.
MLA Shen, Zhanlong,et al."Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis".AMERICAN JOURNAL OF SURGERY 200.1(2010):59-63.
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